细菌性阴道病患者局部IL-2、IL-10水平的研究  

The Study of IL-2 and IL-10 Level in Cervicovaginal Lavage Fluid of Patients with Bacterial Vaginosis

作　　者：周虹[1] 王红霞[1] 刘晓峰[1] 

机构地区：[1]广东省深圳市南山区妇幼保健院,广东深圳518052

出　　处：《实用妇产科杂志》2011年第7期533-535,共3页Journal of Practical Obstetrics and Gynecology

基　　金：广东省深圳市科技计划项目(编号:200703037)

摘　　要：目的:检测细菌性阴道病(BV)患者阴道局部白细胞介素2(IL-2)、白细胞介素10(IL-10)的变化,探讨阴道局部免疫在BV中所发挥的作用。方法:选取BV患者38例作为研究组(BV组),选取同期正常妇女40例作为对照组,用ELISA方法检测两组阴道灌洗液IL-2、IL-10的水平。结果:①BV组阴道灌洗液IL-2水平较对照组显著下降(P=0.007),而IL-10则显著升高(P<0.001);②与对照组相比,BV组阴道灌洗液IL-2/IL-10比值显著性下降(P<0.001)。结论:①BV时阴道灌洗液IL-2下降,提示阴道局部活化T细胞及产生细胞因子的能力减弱,宿主的细胞免疫功能低下;②阴道灌洗液IL-10升高,提示阴道局部抑制前炎症细胞因子产生以及抑制T细胞合成细胞因子,具有抗炎效应;③IL-2/IL-10比值下降提示可能出现了Th1/Th2细胞的免疫功能失衡。Objective：To investigate the variation of interleukine-2（IL-2）,IL-10 in cervicovaginal lavage fluid of women with bacterial vaginosis（BV）,and to analyze the function of local vaginal immunity in bacterial vaginosis（BV）.Methods：Cervicovagial lavage fluid was collected from 38 BV patients（BV group）and 40 healthy women（control group）,The concentrations of IL-2,IL-10 were measured by enzyme-linked immunosorbent assay（ELISA）.Results：①Compared with the level of IL-2,IL-10 in control group,IL-2 decreased significantly（P=0.007）and IL-10 increased significantly（P〈0.001）in BV group.②The ratio of IL-2/IL-10 in BV group was significantly lower than that in control group（P〈0.001）.Conclusions：①The decrease of IL-2 in BV patients suggests the ability of activating T cells and producing cytokines locally in vagina is decreased,and the cellular immunity of host is low.②The increase of IL-10 suggests vagina enviroment can inhibit the production of pro-inflammatory cytokines and T cells to synthesize cytokines,and exibit anti-inflammatory effect.③The decrease of IL-2/IL-10 ratio suggests immune function of Th1/Th2 maybe in unbalance.

关 键 词：细菌性阴道病 白细胞介素2 白细胞介素10 

分 类 号：R711.73[医药卫生—妇产科学]