微囊化胰岛移植与胰岛素注射对实验性糖尿病大鼠血液流变学的影响  

THE EFFECT OF MICROENCAPSULATED ISLET TRANSPLATATION AND INSULIN INJECTION ON HEMORRHEOLOGY OF EXPERIMENTAL DIABETES MELLITUS RATS

作　　者：姜枫勤[1] 任青华[1] 张玉昆[1] 王恒孝[1] 姜国胜[1] 刘金城 

机构地区：[1]山东省医学科学院基础医学研究所 [2]志友公司医院

出　　处：《山东医科大学学报》1999年第4期295-297,共3页Acta Academiae Medicinae Shandong

基　　金：山东省自然科学基金!资助项目部分内容(Z96C01002)

摘　　要：采用微囊化胰岛异种移植治疗实验性糖尿病大鼠，同时观察与常规胰岛素皮下注射在存活率、降血糖、血流变、肝脏超微结构的变化等方面的影响。结果表明，移植组在移植术后７０ｄ 时全部存活，胰岛素治疗组８ 只存活，移植术后１００ｄ 时测得血糖（６．５１±１．０８）ｍ ｍ ｏｌ／Ｌ，与胰岛素注射组（２１．２９±２．４５）ｍ ｍ ｏｌ／Ｌ相比差异有显著性（Ｐ＜ ０．０１）。血流变指标改变如全血高切粘度、低切粘度、细胞聚集指数、高切还原和低切还原粘度等移植组均比胰岛素组降低（Ｐ＜ ０．０５，Ｐ＜ ０．０１）。移植组肝脏超微结构病理改变显著轻于胰岛素治疗组。表明微囊化胰岛移植治疗实验性糖尿病有效，并能降低血流变指标和减缓肝脏的损害。Experimental diabetes mellitus rats were treated with microencapsulated islet transplatation and insulin injection respectively, and blood glucose level, hemorrheology, liver ultrastructure were observed. The results showed that all transplanted group of rats are survive on the 70th day after transplantation, but eight rats were live in the same time in the insulin injection group. The blood glucose level of transplanted group is markedly lower than that of injected group (P<0.01).The index of hemorrheology such as high shear viscosity, low shear viscosity, erythrocyte aggregation index, high and low shear reduce viscosity in the transplanted group is decreased than that of injected group. The pathological change of liver ultrastructure in the transplanted group is lower than that of injection group. The results indicate that microencapsulated islets transplantation improved hemorrheological indexes and reduced liver damage.

关 键 词：微囊化胰岛 糖尿病 血液流变学 胰岛移植 

分 类 号：R587.1[医药卫生—内分泌] R657.5[医药卫生—内科学]