康复新液促进慢性胃溃疡愈合作用的研究  

作　　者：王良[1] 黄秀深[1] 陈瑾 罗雄[1] 冯蓓[1] 

机构地区：[1]成都中医药大学病理实验室,成都611137 [2]四川好医生攀西药业有限责任公司,西昌615000

出　　处：《四川中医》2011年第7期33-35,共3页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:通过康复新液对乙酸烧灼型慢性胃溃疡模型进行干预,旨在探索康复新液促进胃溃疡愈合的作用。方法:采用乙酸烧灼型慢性胃溃疡模型,测定溃疡指数,光学显微镜观察病理。结果:大鼠胃浆膜下注射10%乙酸后,可使胃壁组织受损,溃疡呈圆形或椭圆形,中心凹陷,四周微隆起。镜下可见胃溃疡模型胃组织溃疡部位既有炎性细胞浸润期(P<0.001),又有肉芽组织增生及纤维化(P<0.001),还有黏膜再生(P<0.001)。给药治疗后,康复新液组的溃疡、炎细胞浸润、肉芽组织情况比其他给药组明显轻,粘膜修复程度情况比其他给药组明显好。结论:康复新液有促进粘膜再生及纤维化和缩短溃疡修复时间的作用,且作用明显强于雷尼替丁、奥美拉唑、达喜和康复新液合用西药。Objective： To study the promoting effect of Kangfuxin solution on gastric ulcer healing by intervention of chronic acetic acid model in rats.Methods： Chronic acetic acid model in rats was used to determine ulcer index and observe pathological change by light microscope.Results： After injecting 10%acetic acid under tunica serosa gastria in mice,we have seen the gastric tissue damage and round or ellipse ulcers with depression in central and intumesce in circumference.By microscope,we have seen that gastric ulcer have infiltration of inflammatory cells（P0.001）;have granulation tissue and fibrosis（P0.001）;and also have mucosal regeneration（P0.001）.After administration,the case of ulcers、inflammatory cell infiltration and granulation tissue of Kangfuxin solution group were obvious lighter than other groups,by the way,the degree of mucosal repair of kangfuxin solution group was also better than other groups.Conclusion： Kangfuxin solution has promote mucosal regeneration and fibrosis effects and shorten the time of ulcer repair.Moreover,such effects of Kangfuxin solution are better than ranitidine、omeprazole、hydrotalcite and kangfuxin solution combined with western medicine.

关 键 词：康复新液 乙酸烧灼型慢性胃溃疡 粘膜再生 纤维化 

分 类 号：R285.5[医药卫生—中药学]