感觉神经植入猴失神经无毛皮肤后机械感受器再支配研究(英文)  

Reinnervation of cutaneous mechanoreceptors subsequent to sensory nerve implantation into denervated glabrous skin in monkeys

作　　者：李跃军[1] 陈绍宗[1] 李学拥[1] 程飚[1] 陈辉[1] 曲辉[1] 

机构地区：[1]第四军医大学唐都医院整形外科,陕西西安710038

出　　处：《第四军医大学学报》1999年第11期921-925,共5页Journal of the Fourth Military Medical University

摘　　要：目的：观察猴失神经无毛皮肤中机械感受器在感觉神经植入后的再支配过程，评价再支配感受器的电生理功能．方法：采用神经单纤维引导技术，研究在感觉神经植入术后２，３，５，８，１２ｍｏ时，获得神经再支配机械感受器的快慢适应性、敏感性及检出率变化．结果：神经植入术后２ｍｏ～３ｍｏ是再支配的活跃期，但新生感受器的阈值明显高于正常对照组．经过一个不断成熟的过程，术后１２ｍｏ时原失神经皮肤内获得再支配的机械感受器具有满意的密度和敏感性．在整个再支配和成熟过程中，快适应机械感受器比慢适应机械感受器更容易再生和成熟．结论：猴失神经无毛皮肤内的机械感受器，在感觉神经植入术后１２ｍｏ能获得满意的神经再支配．AIM:The purposes of the present study were:①to observe the reinnervating process of denervated mechanoreceptors in monkeys′ glabrous skin following sensory nerve implantation, and ②to evaluate the electrophysiological function of the reinnervated mechanoreceptors. METHODS: Single nerve fibre recording technique was used to investigate the number and sensitivity of rapidly and slowly adapting reinnervated mechanoreceptors at 2, 3, 5, 8 and 12 months after the operation. RESULTS: In this experiment, the most active period of reinnervating was 2 to 3 months, but the thresholds of newly regenerated receptors were much higher than those of the normal. After a maturing phase, the denervated mechanoreceptors seemed to be reinnervated in 12 months by the implanted sensory nerve with a satisfactory density and sensitivity, though the conduction velocity was not rehabilitated. In the whole process of reinnervation and maturity, the rapidly adapting mechanoreceptors regenerated more easily and better than the slowly adapting ones. CONCLUSION: The results suggest that cutaneous mechanoreceptors in monkeys′ denervated glabrous skin can be reinnervated with a satisfactory recovery in sensory function after nerve implantation. Foundation item: Partly supported by the grant of National Natural Science Foundation No. 39370694 Biographies:LI Yue Jun, male, born on Oct. 1st, 1965 in Xinji city, Hebei Province. Graduated from the Fourth Military Medical University as a bachelor in 1987. Now an attending surgeon and MD candidate whose supervisor is Prof. CHEN Shao Zong. Tel:[phone]; E mail [e-mail] Received date: 1999 06 20; Revised date: 1999 09 20

关 键 词：感觉神经 神经再生 神经电生理 机械感受器 

分 类 号：R622.1[医药卫生—整形外科] R651.1[医药卫生—外科学]