TOLL样受体7表达在系统性红斑狼疮发病机制中的作用  

The role of Toll-like receptor 7 (TLR7) in pathogenesis of lupus nephritis

作　　者：杨京芝[1] 梁鸣[1] 柯莉[1] 李剑文[1] 傅君舟[1] 

机构地区：[1]广州市第一人民医院肾内科,广东广州510080

出　　处：《临床和实验医学杂志》2011年第2期84-86,共3页Journal of Clinical and Experimental Medicine

基　　金：2005广东省自然科学基金资助(5300319);2008年度广州市医药卫生科技项目资助(2008-YB-252)

摘　　要：目的探讨TOLL样受体7在系统性红斑狼疮(SLE)狼疮肾炎的发病机制中的作用。方法利用逆转录-聚合酶链反应(RT-PCR)半定量方法检测30例SLE患者及15例健康对照组外周血中TLR7mRNA的表达水平。结果 SLE患者缓解期组外周血TLR7 mRNA表达水平与正常对照组相比,未显示出统计学差异(P>0.05);外周血TLR7 mRNA表达水平在SLE患者活动期组与正常对照组相比,SLE患者中显著升高(P<0.01);SLE患者外周血TLR7 mRNA的表达水平与SLE活动指数呈正相关,具有统计学意义(r=0.92,P<0.01)。结论提示外周血TLR7mRNA表达水平升高与SLE活动存在联系,TLR7可能参与SLE的发病过程。Objective To study the role of Toll-like receptor 7（TLR7） in pathogenesis of lupus nephritis.Methods The expression levels of TLR7mRNA in 30 SLE patients and 15 healthy controls were measured with semi-quantitative reverse transcription-polymerase chain reaction（RT-PCR）.Resluts There was no significant difference in peripheral blood level of TLR7mRNA between SLE remission group and control group（P0.05）,and the peripheral blood level of TLR7mRNA in patients with active SLE group was significantly higher than that of patients in control group（P0.01）.There was significant positive correlation between peripheral blood level of TLR7mRNA and SLEDAI scores in patients of SLE group,and the difference between SLE group and normal control group was statistically significant（r=0.92,P0.01）.Conclusion The high expression of TLR7mRNA in peripheral blood is considered to be associated with the activity of SLE,thus it suggests that TLR7 may be involved in the process of pathogenesis of SLE.

关 键 词：TOLL样受体7 系统性红斑狼疮 表达 发病机制 

分 类 号：R593.241[医药卫生—内科学]