近红外光谱法应用于奥美拉唑含量分析  

Quantitative analysis on omeprazole by near-infrared spectroscopy

作　　者：林翔[1] 汪学楷[1] 代涛[1] 杨阳[1] 李晖[1] 

机构地区：[1]四川大学化学工程学院,四川成都610065

出　　处：《化学研究与应用》2011年第7期898-901,共4页Chemical Research and Application

摘　　要：基于近红外光谱分析技术建立奥美拉唑定量分析方法。以高效液相色谱法作为参考方法,采用偏最小二乘法(PLS)对同一厂家不同批号的奥美拉唑肠溶胶囊建立校正模型,所建模型相关系数(R)为0.978,校正均方差(RMSEC)为0.0899,交叉验证均方差(RMSECV)为0.182,校正模型的预测均方差(RMSEP)为0.161。由于该方法无需对样品进行复杂的前处理,准确、快速、简便,在实际工艺生产及药品质量监控中具有应用前景。To develop a rapid determination method of Omeprazole in Omeprazole Enteric-Coated Capsules from different batch in the same factory by Near-infrared spectroscopy technique.Through collecting Near-infrared spectra,with HPLC values as reference,the quantitative calibration model was built by partial least squares（PLS）.The correlation coefficient（R）was 0.978,the root mean squared error of calibration（RMSEC）and root mean squared error of cross-validation（RMSECV）were 0.0899 and 0.182,and root mean squared error of prediction（RMSEP）was 0.161.Conclusion：The method is fast,accurate and not required complicated pre-treatment,and it provides a promising application for pharmaceutical production process and quality control.

关 键 词：近红外光谱 偏最小二乘法 奥美拉唑 定量分析 

分 类 号：O657.33[理学—分析化学]