石墨烯修饰玻碳电极伏安法测定酪氨酸  

Voltammetric determination of tyrosine with graphene modified glassy carbon electrode

作　　者：许春萱[1] 黄克靖[1] 余萌[1] 樊阳[1] 王月霞[1] 

机构地区：[1]信阳师范学院化学化工学院,河南信阳464000

出　　处：《化学研究与应用》2011年第7期943-946,共4页Chemical Research and Application

基　　金：河南省高校科技创新人才基金项目(2010HASTIT025)资助;河南省科技创新人才项目(104100510020)资助

摘　　要：制备了石墨烯修饰玻碳电极,研究了酪氨酸在修饰电极上的电化学行为。优化了包括支持电解质、溶液pH、修饰剂用量、富集电位及时间等测定条件。在0.1 mol.L-1 pH 7.0的磷酸盐缓冲溶液中,峰电流与酪氨酸的浓度在3×10-6～1.2×10-4mol.L-1的范围内呈良好的线性关系,检出限为2×10-7 mol.L-1(S/N=3)。将该法用于药物中酪氨酸的测定,平均回收率在92.6%～109.2%之间。A novel electrochemical method was developed for the detection of tyrosine based on the graphene modified glassy carbon electrode.The experimental parameters such as the supporting electrolyte,buffer pH,the amount of graphene suspension,the accumulation potential and time,were optimized in detailed.The results showed that the peak currents varied linearly with the concentration of tyrosine over the range from 3×10-6 to 1.2×10-4 mol·L-1 with the detection limit of 2×10-7 mol·L-1 in a pH 7 phosphate buffer solution（S/N=3）.Using this modified electrode,trace level of tyrosine in pharmaceutical and clinical preparations was determined with recoveries in the range of 92.6%-109.2%.

关 键 词：石墨烯 差分脉冲伏安法 酪氨酸 化学修饰电极 

分 类 号：O657.1[理学—分析化学]