无细胞和全细胞百白破疫苗接种不良反应观察  

Observation on Adverse Reaction of Diphtheria,Tetanus and Acellular Pertusis Combined Vaccine and Diphtheria,Tetanus and Whole-cell Pertusis Combined Vaccine

作　　者：杨洁[1] 何梅英[1] 单芙香[2] 旷翠萍[1] 

机构地区：[1]深圳市罗湖区疾病预防控制中心,广东深圳518021 [2]深圳市疾病预防控制中心

出　　处：《实用预防医学》2011年第7期1225-1227,共3页Practical Preventive Medicine

基　　金：2010年深圳市罗湖区软科学研究计划项目(2010067)

摘　　要：目的比较接种吸附无细胞百白破疫苗(DTaP)与全细胞百白破疫苗(DTwP)后发生疑似预防接种异常反应的差异。方法对2009年1月-2010年12月在辖区内预防接种门诊接种百白破疫苗出现疑似预防接种异常反应进行回顾性分析。结果 62 214名接种DTaP者发生疫苗疑似预防接种异常反应8例,反应率12.86/10万;62 182名接种DTwP者发生疫苗疑似预防接种异常反应54例,反应率86.84/10万;DTwP反应发生率高于DTaP,差异有统计学意义(P<0.01)。结论 DTaP的接种副反应较DTwP低、安全性好,接种百白破联合疫苗时最好使用吸附无细胞百白破疫苗(DTaP)。Objective To compare the difference abnormal reaction in prevontive vaccination between absorbed diphtheria,tetanus and acellular pertusis combined vaccine（DTaP） and absorbed diphtheria,tetanus and whole-cell pertusis combined vaccine（DTwP）.Methods Retrospective analysis on suspected adverse events following immunization（AEFI） of diphtheria,tetanus and pertusis combined vaccine in Luohu Distric during Jan 2009-Dec 2010.Results Eight AEFI cases were observed in 62 214 cases vaccinated with DTaP.The reaction rate was 12.86/100,000.In 62 182 cases vaccinated with DTwP,54 AEFI cases were observed.The reaction rate was 86.84/100,000.The reaction rate in DTwP group was higher than the DTaP group（with statistical significance,P0.01）.Conclusions The adverse reaction rate of DTaP is comparatively lower.DTaP is safe and recommended for vaccination.

关 键 词：无细胞百白破疫苗 全细胞百白破 预防接种异常反应 

分 类 号：R186[医药卫生—流行病学]