慢性低氧脾脂质沉积  

SPLENIC LIPIDOSIS IN RATS EXPOSED TO CHRONIC HYPOXIA

作　　者：瓦龙美[1] 瓦龙德[2] 

机构地区：[1]首都医科大学组织学与胚胎学教研室,北京100054 [2]贵州财经学院

出　　处：《解剖学杂志》1999年第6期514-517,共4页Chinese Journal of Anatomy

摘　　要：目的：探讨慢性低氧脾组织的病理学改变。方法：将Ｗｉｓｔａｒ大鼠喂养在逐渐降低的常压低氧条件下，用氮气和空气的混合气体调节氧含量，氧浓度由常含量逐步降低为１５％，１２％，１０％，８％，最后降为７％，实验共进行１１２天。结果：低氧大鼠体重下降，脾重增加，红髓增生，脾血管壁增厚，脾内出现较多泡沫细胞。白髓减少，脾小体萎缩或消失。结论：长期慢性严重低氧可导致脾脂质沉积，免疫能力下降。Rats were exposed to chronic normobaric hypoxia which the oxygen concentration decreased from 15%, 12%, 10%, 8% to 7% to study the pathological changes of the splenic tissues in chronic hypoxia. The hypoxic experiment continued for 112 dyas. The results showed that chronic hypoxia made the decrease of the body weight and the increase of the splenic weight, hyperplasia of rad pulp, thickening of the splenic arteriolar walls, the presence of more foam cells in the spleen, and the atrophy of the white pulp and the splenic corpuscle. These findings indicates that severe chronic hypoxia induces splenic lipidosis and the decrease of immune activity of spleen.

关 键 词：脾 脂质沉积 低氧 

分 类 号：R551.102[医药卫生—血液循环系统疾病]