四逆散冻干粉对剥夺睡眠果蝇的睡眠影响  

The Effection of Lyophilized Powder of Sinisan on Sleep Duration in Sleep Deprived Drosophila

作　　者：李玉萍[1] 徐瑞鑫[1] 李廷利[1] 张茹[1] 

机构地区：[1]黑龙江中医药大学药学院,哈尔滨150040

出　　处：《寄生虫与医学昆虫学报》2011年第2期111-114,共4页Acta Parasitologica et Medica Entomologica Sinica

基　　金：国家自然科学基金项目（No.30672634）

摘　　要：近年来日内外科学家将果蝇作为一种模式生物进行睡眠研究，希望能够通过对这种相对简单的生物的睡眠过程的研究，加速人类对睡眠认识的进程。本实验观察四逆散冻干粉对睡眠剥夺模型果蝇的睡眠改善作用。采用光照刺激剥夺睡眠和机械刺激剥夺睡眠两种方法复制果蝇睡眠剥夺模型，利用果蝇DAMS监测器和数据采集自动记录系统评价，以果蝇24h累积睡眠时间为观察指标，观察各组果蝇睡眠时间。结果显示，与空白组比较，睡眠剥夺组果蝇睡眠时间明显减少，具有显著性差异（P〈0．05），说明果蝇睡眠剥夺模型造模成功；与睡眠剥夺模型组比较，给药组果蝇睡眠时间明显延长，具有极显著性差异（P〈0．01），说明四逆散冻干粉对两种睡眠剥夺模型果蝇睡眠均有一定的改善作用。#In recent years, Drosophila is a model organism for sleep by domestic and foreign scientists, to further understand human sleep, through this relatively simple biological processes of sleep. The experimental observation of Lyophilized Powder of Sinisan on sleep deprivation （SD） improve Drosophila Sleep Time. SD by light stimulation and mechanical stimulation are two ways to copy models, using DAMS monitors and data acquisition system to evaluate flies 24 h accumulated sleep time, it was observed to result in each group. The results show that compared with the control group, SD group flies sleep time was significantly reduced, with significant difference （P 〈 0.05 ） , this result indicates Drosophila SD model was successful, and compared with SD group, treatment group was significantly longer sleep time, with highly significant difference （ P 〈 0. 01 ） , this result indicates Lyophilized Powder of Sinisan on SD improve Drosophila Sleep Time.

关 键 词：四逆散 冻干粉 果蝇 睡眠剥夺 

分 类 号：Q428[生物学—神经生物学]