托烷司琼与昂丹司琼预防全麻下子宫全切术患者术后恶心呕吐的疗效观察  

Effect of Tropisetron and Ondansetron on Postoperative Nausea and Vomiting in Patients Undergoing Abdominal Hysterectomy under General Anesthesia

作　　者：钱金桥[1] 陈红梅 毕春[1] 陈燕[1] 叶佩[1] 

机构地区：[1]昆明医学院第一附属医院麻醉科,云南昆明650032 [2]昆明同仁医院麻醉科,云南昆明650228

出　　处：《昆明医学院学报》2011年第6期81-84,共4页Journal of Kunming Medical College

摘　　要：目的比较托烷司琼与昂丹司琼预防全麻妇科手术后恶心呕吐的效果.方法选择135例择期全麻下行腹式子宫全切除术患者(ASAⅠ～Ⅱ级),随机分为3组(n=45),分别于术毕拔管前缓慢静注生理盐水4 mL,托烷司琼4 mg/mL,昂丹司琼8 mg/4 mL,观察术后24 h内恶心呕吐情况并作比较.结果托烷司琼和昂丹司琼抑制术后24 h恶心呕吐的发生率分别为73%和60%,显著高于对照组33%(P<0.05).与对照组相比,托烷司琼和昂丹司琼都可有效降低恶心呕吐的发生(P<0.05),但托烷司琼组和昂丹司琼组之间差异无统计学意义(P>0.05).结论术后拔管前静注托烷司琼4 mg或昂丹司琼8 mg均能有效预防或减轻术后恶心呕吐.Objective To compare the efficacy of tropisetron and ondansetron in the prevention of postoperative nausea and vomiting after gynecological surgery under general anesthesia.Methods Forty-five ASAⅠ～Ⅱ patients undergoing abdominal hysterectomy under general anesthesia were randomly divided into three groups（n=45）.At the end of the surgery,the patients were given intravenously tropisetron 4 mg,ondansetron 8 mg,or normal saline respectively.The episodes of nausea and vomiting were observed for 24 h after operation.Results The effective rate of tropisetron and ondansetron to inhibit the incidence of postoperative nausea and vomiting was 73% and 60% respectively.Both of them significantly reduced the degree of postoperative nausea and vomiting（P0.05）.There was no significant difference between tropisetron and ondansetron in efficacy（P0.05）.Conclusion Intravenous injection of tropisetron 4 mg or ondansetron 8 mg at the end of the surgery can significantly reduce the incidence of postoperative nausea and vomiting in patients undergoing abdominal hysterectomy under general anesthesia.

关 键 词：托烷司琼 昂丹司琼 子宫切除术 手术后恶心呕吐 

分 类 号：R969.4[医药卫生—药理学]