二氧化碳激光灸影响膝骨关节炎患者生活质量的随机双盲对照  

Effects of CO_2 laser moxibustion on quality of life in patients with knee osteoarthritis:A double-blind randomized controlled trial

作　　者：吴凡[1] 张海蒙[1] 王丽祯[1] 赵玲[1] 邓海平[1,2] 程珂[1,2] 沈雪勇[1,2] 

机构地区：[1]上海中医药大学,上海市201203 [2]上海市针灸经络研究中心,上海市201203

出　　处：《中国组织工程研究与临床康复》2011年第26期4885-4890,共6页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家973计划(2009CB522901);国家中医药管理局和上海市重点学科建设项目(S30304);上海市青年科技启明星计划项目(10QA1406400);国家自然科学基金项目(30801489);上海高校选拔培养优秀青年教师科研专项基金(szy08022);上海市科技发展基金科技攻关项目(08DZ1972801;08DZ1973000)~~

摘　　要：背景:目前临床上应用激光针灸治疗膝骨关节炎的研究主要集中在改善疼痛及关节功能方面,对患者生活质量的情况鲜有报道或仅作为次要观察指标进行描述。目的:观察二氧化碳激光灸对膝骨关节炎患者生活质量的影响。方法:将31例膝骨关节炎患者随机分为治疗组和对照组分别接受为期4周,每周3次,每次20min的二氧化碳激光照射犊鼻穴治疗和假治疗。结果与结论:治疗组身体功能在治疗4周和随访时得分均明显优于治疗前(P=0.031,P=0.006);治疗组身体疼痛和健康感受在随访时得分均明显优于治疗前(P=0.007,P=0.011)。治疗组在治疗2周时身体功能和身体功能对角色的限制得分明显优于对照组(P=0.033);治疗组在随访时身体功能得分亦优于对照组(P=0.021)。治疗组身体疼痛得分改善趋势明显优于对照组(P=0.037)。提示CO2激光灸对膝骨关节炎患者在身体功能和身体疼痛方面的生活质量改善明显优于对照组。BACKGROUND：Currently,there are only a few clinical reports on the efficacy of laser moxibustion for knee osteoarthritis,and most of them focus on pain and joint function improvement after treatment.The life quality of patients is rarely observed or reported only as a minor measurement.OBJECTIVE：To observe effects of CO2 laser moxibustion on quality of life in patients with knee osteoarthritis.METHODS：Thirty-one cases were included in accordance with the inclusion criteria and divided into a treatment group（15 cases,with CO2 laser moxibustion treatment on ST-35） and a control group（16 cases,without laser treatment） with a double-blind,randomized and controlled method.Patients of both groups received 20 minutes＇ treatment,thrice a week and 4 weeks in total.RESULTS AND CONCLUSION：Scores of physical functioning（PF） in the treatment group was significantly improved after 4 weeks＇ treatment as well as in the follow-up（P=0.031,P=0.006）.Scores of bodily pain（BP） and general health（GH） in the treatment group was significantly superior in the follow-up compared with those before treatment（P=0.007,P=0.011）.After 2 weeks＇ treatment,scores of PF and role limitations-physical（RF） in the observation group was significantly superior to those in the control group（P=0.033）.Significant difference was also presented in scores of PF in the follow-up between two groups（P=0.021）.Scores of BP in the treatment group showed higher tendency of improvement than that of the control group（P=0.037）.Compared with the control group,CO2 laser moxibustion treatment could better improve quality of life in patients with knee osteoarthritis in respect of bodily function and pain.

关 键 词：膝骨关节炎 二氧化碳激光灸 生活质量 36条目简明健康调查量表 穴位 犊鼻 随机 对照 双盲 

分 类 号：R318[医药卫生—生物医学工程]