降钙素促进骨质疏松骨床中植入体的骨整合(英文)  

Calcitonin promotes implant osteointegration in osteoporosis condition

作　　者：陈柏龄[1] 谢登辉[1] 吕维加[2] 李佛保[1] 廖威明[1] 黎艺强[1] 

机构地区：[1]中山大学附属第一医院骨科,广东省广州市510080 [2]香港大学医学院创伤与矫形外科系

出　　处：《中国组织工程研究与临床康复》2011年第26期4927-4930,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:降钙素具有提高骨量、骨质量,降低骨折发生的效果。目的:评价鲑鱼降钙素对羟基磷灰石植入体骨整合的影响,及其在治疗骨质疏松症同时促进植入体生物学固定的能力。方法:将SD大鼠随机分为假手术+羟基磷灰石棒组、卵巢切除+羟基磷灰石棒组、卵巢切除+降钙素+羟基磷灰石棒组,后2组建立绝经后骨质疏松动物模型。建模后分别在3组大鼠的胫骨平台处开孔植入多孔羟基磷灰石假体,卵巢切除+降钙素+羟基磷灰石棒组大鼠皮下注射鲑鱼降钙素12周。结果与结论:卵巢切除后,大鼠的腰椎骨密度降低,而持续皮下注射鲑鱼降钙素后,大鼠的腰椎骨密度逐渐改善。应用降钙素处理后的大鼠,其骨结合率较卵巢切除+羟基磷灰石棒组提高了22.0%(P<0.05)。结果证实,全身给予鲑鱼降钙素能提高骨质疏松大鼠骨床和植入体周围骨量、促进主体骨-植入体的骨整合。BACKGROUND：Calcitonin can increase bone quantity and quality so as to reduce bone fracture occurrence.OBJECTIVE：To evaluate the effects of calcitonin on implant＇s osteointegration and further on promoting the biological fixation of implants in osteoporotic condition.METHODS：Sprague-Dawley rats were randomly divided into three groups：sham surgery ＋ hydroxyapatite（HA）,ovariectomy（OVX） ＋ HA,and OVX ＋ calcitonin ＋ HA groups.Postmenopausal osteoporosis models were established in the OVX ＋ HA and OVX ＋ calcitonin ＋ HA groups.The porous HA prostheses were inserted into the tibial platform in each group after model induction,and rats in the OVX ＋ calcitonin ＋ HA group were given calcitonin for 12 weeks by subcutaneous injection.RESULTS AND CONCLUSION：Lumbar vertebral bone mineral density（BMD） decreased in OVX ＋ HA group,and the lumbar BMD increased in the OVX ＋ calcitonin ＋ HA group after administration of calcitonin.Comparing with that in OVX ＋ HA group,osseointegration rate in OVX ＋ calcitonin ＋ HA group was increased by 22.0%（P 0.05）.Results verified that in osteoporotic condition,subcutaneous administration of calcitonin could increase bone mass surrounding the implants and promote osteointegration.

关 键 词：鲑鱼降钙素 羟基磷灰石 骨整合 骨质疏松 硬组织移入物 

分 类 号：R318[医药卫生—生物医学工程]