C57BL/6小鼠在烧伤及药理学实验中的Meeh常数取值  

Calculation of a Meeh constant during thermal injury and pharmacology experiments in C57BL/6 mouse

作　　者：廖庚进[1] 付晋凤[1] 罗鹏飞[2] 贾一韬[2] 孙瑜[2] 金以超[1] 夏照帆[2] 

机构地区：[1]昆明医学院第二附属医院烧伤科,云南省650101 [2]上海第二军医大学长海医院烧伤科

出　　处：《江苏医药》2011年第14期1626-1628,共3页Jiangsu Medical Journal

基　　金：国家自然科学基金重点项目(30730091)

摘　　要：目的研究在烧伤及药理学实验中计算C57BL/6小鼠全身体表面积(BSA)时Meeh常数(k)的取值。方法测量20只C57BL/6小鼠的体重和BSA,并计算出小鼠的实际k值,比较其与5个正常小鼠常用k值(6.0、9.1、9.5、10.0和11.4)间的差异。结果小鼠BSA计算所得的k值为9.715±0.142,与正常小鼠常用k值比较差异均有统计学意义(P<0.01)。结论应用Meeh公式计算C57BL/6小鼠的BSA时,k值宜选用9.715。Objective To investigate the proper Meeh constant（k） for calculating the body surface area（BSA） of C57BL/6 mouse in the experiments of burn and pharmacology study.MethodsThe body weight and BSA of twenty C57BL/6 mice were measured.The k value of each mouse was calculated and compared with the five common k values （6.0,9.1,9.5,10.0 and 11.4） in normal mice.Results The calculated k value in this group was 9.715±0.142,which was significantly different from the five frequently-used k values（P0.01）.Conclusion A k value of 9.715 should be taken for calculating the BSA of C57BL/6 mouse.

关 键 词：烧伤 体表面积 Meeh常数 

分 类 号：R644[医药卫生—外科学]