慢性肾脏病患者血清甲状腺激素测定的临床意义  

The significance of detecting serum thyroid hormones in patients with chronic kidney disease

作　　者：王慧敏[1,2] 崔丽娟[1,2] 魏玮[1,2] 孙瑶[1,2] 

机构地区：[1]中国医科大学第五临床学院 [2]辽宁本溪钢铁公司总医院肾脏病科,本溪市117000

出　　处：《江苏医药》2011年第14期1652-1654,共3页Jiangsu Medical Journal

摘　　要：目的观察慢性肾脏病(CKD)患者血清甲状腺激素(TH)的变化。方法选择50例CKD患者作为观察组(CKD组),50例同期进行体检的健康人作对照组,测定血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)浓度及肾功能。结果 CKD组FT3(1.76±0.23)pmol/L、FT4(7.26±1.38)pmol/L,明显低于对照组的(5.42±0.56)pmol/L、FT4(16.54±3.73)pmol/L(P<0.05)。CKD组FT3、FT4分别与血尿素氮、肌酐呈负相关(P<0.01)。结论动态监测CKD患者血清TH的变化,对于判断患者的病情轻重与预后具有重要的参考价值。Objective To investigate the changes of serum thyroid hormone levels in the patients with chronic kidney disease（CKD）.Methods Serum free triodothyronine（FT3）,free tetraiodothyronine（FT4）,thyrotropin（TSH） and renal function were examined in 50 CKD patients（group CKD） and 50 healthy persons（group C）.Results Serum FT3 and FT4 in group CKD were（1.76±0.23） pmol /L and（7.26±1.38） pmol/L,which were lower than（5.42 ±0.56） pmol/L and （16.54±3.73） pmol/L in group C（P0.05）.Serum levels of FT3 and FT4 were negatively correlated to those of BUN and Cr（P0.01）.Conclusion Dynamically observing the changes of serum thyroid hormones is valuable in predicting the severity and prognosis in CKD patients.

关 键 词：慢性肾脏病 甲状腺激素 

分 类 号：R692[医药卫生—泌尿科学]