新型生物活性物质尾加压素Ⅱ降眼压作用的实验研究  

Experimental study of intraocular pressure decreased by new biological activity substance of Urotensin Ⅱ

作　　者：李坤鹏[1] 黄秀榕[1] 祁明信[2] 陈义[1] 

机构地区：[1]福建中医药大学病理生理研究中心,中国福建省福州市350003 [2]福建中医药大学附属第二人民医院眼科,中国福建省福州市350003

出　　处：《国际眼科杂志》2011年第8期1334-1336,共3页International Eye Science

基　　金：中国福建省中医药重点科研资助项目(No.Wzz-b0601)~~

摘　　要：目的:探讨尾加压素Ⅱ(urotensinⅡ,U-Ⅱ)对兔眼压的影响。方法:将10,100pg/μL和1,10ng/μL浓度的U-Ⅱ溶液10μL分别注射到新西兰白兔眼玻璃体前部,于注射后即刻(0h),1,2,4,6,8,10,12,24,36h;2,3,4,5,6d不同时间点,用修兹眼压计行双砝码法眼压测量。结果:0.1ngU-Ⅱ组在10～12h使眼压降低17.5%(P<0.001);1ngU-Ⅱ组在8h使眼压降低33.7%(P<0.001);10ngU-Ⅱ组在6h使眼压降低54.7%(P<0.001);100ngU-Ⅱ组在6h使眼压降低56.4%(P<0.001)。四组降眼压作用分别持续24h;2,3,4d。结论:U-Ⅱ具有快速、强效、持久的降低眼压的作用,有可能成为防治青光眼的有效药物。AIM： To study the effect of Urotensin Ⅱ （U-Ⅱ） on intraocular pressure（lOP）. METHODS： Different concentrations of U- Ⅱ （10pg/μL, 100pg/μL,lng/μL, 10ng/μL） were injected into anterior vitreous body of eyes in New Zealand rabbits. Schiotz impression tonometer were used with double balances after 0,1 hour;2,4,6,8,10,12,24,36 hours;2,3,4,5,6 days. RESULTS： lOP decreased 17.5%, 33.7%, 54.7% and 56.4%（P〈0.001） in groups of 0.1rig U-Ⅱ, 1ng U-Ⅱ, 10ng U-Ⅱ and 100ng U-Ⅱ after 10-12 hours, 8 hours, 6 hours and 6 hours respectively; The effects of lOP decreases continued until 24 hours; 2, 3, 4 days respectively. CONCLUSION： U-Ⅱ can decrease intraocular （IOP） rapidly,intensively and continuously. U- Ⅱ biological activity substance may become an medicine to prevent and treat glaucoma. pressure ,the new effective

关 键 词：尾加压素Ⅱ 眼压 青光眼 兔 

分 类 号：R965[医药卫生—药理学]