头孢呋辛静脉滴注致血小板减少  

Thrombocytopenia induced by intravenous infusion of cefuroxime

作　　者：吴志恒[1] 杨波[1] 

机构地区：[1]武警医学院附属医院药剂科,天津300162

出　　处：《药物不良反应杂志》2011年第3期185-185,共1页Adverse Drug Reactions Journal

摘　　要：1例70岁女性患者拟行脑膜瘤切除术，术前因肺部感染给予头孢呋辛2g溶于0．9％氯化钠溶液250ml，1次／d静脉滴注。用药前血小板166×10^9／L，用药第2天血小板急剧下降至40×10^9／L，但无临床出血表现。考虑可能与头孢呋辛有关，遂停用该药，改用氧氟沙星，换药1d后血小板上升至160×10^9／L。随后肺部感染好转，手术顺利完成。A 70-year-old woman was planned to undergo meningeoma resection and received an IV infusion of cefuroxime 2 g dissolved in 250 ml of 0.9% sodium chloride once daily for a lung infection before operation. Her platelet count was 166 ×10^9/L before drug administration and, on day 2 of treatment, her platelet count rapidly dropped to 40 ×10^9/L, but no evidence of clinical bleeding. It was considered to be associated with eefuroxime, so the drug was withdrawn and switehed to ofloxaein. One day after change to ofloxaein, her platelet count rose to 160 ×10^9/L. Thereafter, the pulmonary infection improved and the operation completed uneventfully.

关 键 词：头孢呋辛 血小板减少 

分 类 号：R595.3[医药卫生—内科学]