曲妥珠单抗引起过敏样反应  

Anaphylactoid reactions induced by trastuzumab

作　　者：贾荣娣[1] 徐遥[1] 

机构地区：[1]江苏大学附属医院药剂科,江苏镇江212001

出　　处：《药物不良反应杂志》2011年第3期198-199,共2页Adverse Drug Reactions Journal

摘　　要：1例52岁女性患者,因乳腺癌术后辅助化疗给予曲妥珠单抗220mg加入0.9%氯化钠注射液250ml静脉滴注,滴速为50滴/min。输入约30min时,患者出现寒战、胸闷、口唇发麻、呼吸困难,心率165次/min,血压199/99mm Hg。立即停止输液,行对症治疗。50min后上述症状消失,心率及血压恢复正常。21d后再次化疗,曲妥珠单抗110mg加入0.9%氯化钠注射液250ml静脉滴注,滴速30滴/min。5min后,患者再次出现过敏样症状。停药10min后症状消失。A 52-year-old woman received an IV infusion of trastuzumab 220 mg dissolved in 0.9% sodium chloride 250 ml at a rate of 50 drops/min for adjuvant chemotherapy after breast cancer surgery. About 30 minutes after infusion initiation, the patient developed chills, chest tightness, lips numbness, and short of breath. Her heart rate was 165 beats/min and blood pressure was 199/99 mm Hg. The infusion was stopped immediately and symptomatic treatment was given. Fifty minutes later, the above symptoms disappeared and her heart rate and blood pressure returned to normal. Twenty-one days later, she received a second chemotherapy with an IV infusion of trastuzumab 110 mg in 0.9% sodium chloride 250 ml at a rate of 30 drops/min. Five minutes later, she presented with anaphylactoid symptoms again and, 10 minutes after drug discontinuation, her symptoms disappeared.

关 键 词：曲妥珠单抗 过敏样反应 

分 类 号：R595.3[医药卫生—内科学]