腺嘌呤诱导的肾性贫血的大鼠模型  

Rat model of adenine induced chronic renal anemia

作　　者：朱小南[1] 潘敬运[1] 王锦群[1] 郑树森[1] 

机构地区：[1]中山医科大学药理学教研室

出　　处：《中国药理学通报》1999年第3期277-279,共3页Chinese Pharmacological Bulletin

摘　　要：目的建立慢性贫血的大鼠模型。方法用０７５％的腺嘌呤（Ｗ／Ｗ）长期饲养大鼠。结果红细胞数、血红蛋白浓度和网织红细胞数明显减少。出现氮质血症和与人类相似的肾脏病理改变。结论用腺嘌呤可诱导大鼠肾性贫血模型。AIM To establish the rat model of chronic renal anemia. METHODS The rats were fed with adenine for a long time. RESULTS The number of red blood cell, hemoglobin concentration and reticulocyte were greatly decreased. Azotemia of human. CONCLUSION Rat model of chronic renal could be induced by adenine.

关 键 词：腺嘌呤 肾性贫血 促红细胞生长素 

分 类 号：R556.9[医药卫生—血液循环系统疾病] R973.3[医药卫生—内科学]