连续给酒精及重复电休克对小鼠学习记忆的影响  

Influence of continuous alcohol treatment and consecutive electroconvulsive shock on learning and memory in mice

作　　者：王圣平[1] 尚伟芬[1] 宋洁[1] 刘新民[1] 孙绍美[1] 

机构地区：[1]中国协和医科大学中国医学科学院药用植物研究所

出　　处：《中国药理学通报》1999年第3期279-282,共4页Chinese Pharmacological Bulletin

摘　　要：目的观察一次性给酒精、一次性电休克与连续给酒精、重复电休克对小鼠学习记忆的影响。方法以昆明种小鼠为材料，从行为学角度，利用跳台、避暗及水迷宫计算机自动分析处理系统检测小鼠的学习记忆能力。结果一次性给２０％～３０％的酒精及一次性电休克对小鼠的学习记忆能力无影响，４０％的酒精能明显影响小鼠的运动功能；连续２ｗｋ给２０％～３０％的酒精能明显引起小鼠跳台作业中再现障碍、水迷宫中空间辨别障碍及避暗作业中获得障碍，而不影响避暗作业中的记忆再现；重复电休克只引起小鼠明暗觉（避暗）巩固障碍，对空间位置觉（跳台）和空间方位觉（水迷宫）无明显影响。结论连续给酒精及重复电休克造成记忆障碍明显，操作简单，为进一步研究学习记忆机制提供了可靠的行为学依据。AIM To observe the influence of continuous alcohol treatment(CAT) and consecutive electroconvulsive shock(CECS) on learning and memory in mice. METHODS By the way of one trial passive avoidance response(step down, step through) and water maze methods to test the ability of learning and memory in mice. RESULTS The memory impairments of acquisition, consolidation and recognition were induced by CAT in step through, CECS in step through and CAT in step down and water maze respectively. However, no impairment on learning and memory could be found in each method when alcohol and ECS were given only one time. CONCLUSIONS The results have showed that CAT and CECS were ideal animal model of dementia.

关 键 词：酒精 电休克 学习记忆 

分 类 号：R971[医药卫生—药品] R749.5[医药卫生—药学]