早发冠心病危险因素的研究  

A Study on Risk Factors of Premature Coronary Heart Disease

作　　者：黄久仪[1,2] 徐德忠[1,2] 李良寿[1,2] 贾国良[1,2] 李兰荪[1,2] 石丘玲[1,2] 何耀[1,2] 孙长生 王嫣[1,2] 阎明晓[1,2] 

机构地区：[1]第四军医大学流行病学教研室 [2]第四军医大学西京医院心内科

出　　处：《中国慢性病预防与控制》1999年第3期102-104,共3页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：对４３４例冠心病患者以规范的流行病学调查方法对常见危险因素进行了调查和测量，分成中青年组、老年前期组和老年组三个年龄层比较早发和晚发冠心病的危险因素的异同。单因素分析显示：早发冠心病的主要危险因素是男性、吸烟史、冠心病、高血压和脑卒中家族史，其优势比（ＯＲ）分别为３．４５、２．５８、２．１４、２．０７和２．０８，早发冠心病组每日吸烟量显著高于其他两组（Ｐ＜０．０５）。多因素分析结果显示：被筛选进入Ｌｏｇｉｓｔｉｃ回归方程的变量是高血压病史、高血压和冠心病家族史、每日吸烟量、血清总胆固醇和高密度脂蛋白水平。An epidemiological investigation on major risk factors of coronary heart disease(CHD) was conducted in 434 CHD patients.Participants were divided into three groups(young and middle age,preelderly and elderly)according to age.Univariable analysis indicated that odds ratio(OR) of family history of CHD was 2.97(95% CI,1.395.82) when compared with preelderly group.With respect to elderly group,odds ratios of male,cigarette smoking,family history of CHD,hypertension and stroke were 3.45(95%CI,1.47￣8.35),2.58(95% CI,1.38￣4.86),2.14(95%CI, 1.10￣4.15),2.07(95% CI,1.18￣3.69) and 2.08(95% CI,0.99￣4.7) respectively.Means of cigarette smoking perday in youngest group was significantly higher than that of two elder groups.Multiple variables analysis indicated that variables being selected into Logistic equation in former analysis were physical exercise,family history of CHD and number of cigarettes perday and in latter analysis were history of hypertension,family history of CHD and hypertension,means of cigarette perday and level of serum high density lipoprotein(HDLC) and total cholesterol(TC).In conclusion,male,cigarette smoking,family history of CHD,hypertension and stroke,elevated TC level and decreased HDLC level may contribute to development of premature CHD.

关 键 词：冠心病 危险因素 年龄 

分 类 号：R541.402[医药卫生—心血管疾病]