锌的排铅作用及对铜 铁元素的影响  

The effect of zinc on lead expelling,copper and iron in lead toxicity mice

作　　者：丁世彬[1] 廖丹[1] 田翀[1] 任玮叶[1] 应晨江[1] 

机构地区：[1]华中科技大学同济医学院公共卫生学院营养与食品卫生学系,武汉430030

出　　处：《微量元素与健康研究》2011年第4期1-3,共3页Studies of Trace Elements and Health

基　　金：国家自然科学基金资助项目(30972473);天峡鲟龙股份公司资助

摘　　要：目的:探讨锌的排铅作用及对血液和股骨中铜、铁元素的影响。方法:小鼠连续30 d饮用0.55%醋酸铅水溶液制作铅中毒模型,同时硫酸锌水溶液灌胃为加锌组,依地酸二钠钙注射为阳性药物对照。结果:加锌组小鼠血铅和股骨铅明显降低,血铁和股骨锌含量明显高于铅中毒模型组;其股骨中的锌、铁和锌/铜均明显高于依地酸二钠钙组。结论:硫酸锌对于铅中毒小鼠具有促进排铅作用,它在维持小鼠股骨中微量元素方面优于依地酸二钠钙。Objective: To observe the effect of zinc on lead expelling,blood and femur copper and iron in lead toxicity mice.Methods: Mice administered with 0.55 g/L lead acetate solution in drinking water for 30 days were used as lead poisoned group,and the mice of zinc supplement group was simultaneously administered with zinc sulfate by gavages.A positive drug control group was setup by simultaneous CaNa2-EDTA injection.Results: Blood and femur lead levels of mice in zinc supplement group decreased significantly with their blood iron and zinc levels higher than that of lead poisoned mode group;the femur zinc、iron and zinc/copper are much higher than those in CaNa2-EDTA group.Conclusion: Zinc sulfate could enhance lead expelling in lead poisoned mice as effectively as CaNa2-EDTA treatment.

关 键 词：锌 排铅作用 微量元素 小鼠 

分 类 号：O614.241[理学—无机化学]