羧甲基壳聚糖—锌络合物的制备及对大鼠血清SOD活性的影响  

Preparation of carboxymethyl Chitosan complexe with Zinc(Ⅱ) and study on its effect on serum SOD activity in rats

作　　者：曹朝晖[1] 李邦良[1] 胡小波[1] 

机构地区：[1]南华大学生化与分子生物学教研室,湖南衡阳421001

出　　处：《微量元素与健康研究》2011年第4期4-6,共3页Studies of Trace Elements and Health

基　　金：湖南省衡阳市科技局资助项目(2009ks33)

摘　　要：目的:研究羧甲基壳聚糖与锌(Ⅱ)络合物的制备并初步探讨其对抗氧化酶SOD活性的影响。方法:用水溶性的羧甲基壳聚糖与锌(Ⅱ)制备络合物,用红外、紫外光谱等初步分析络合物的理化性质,并研究该络合物对饲高糖高脂大鼠血清SOD活性的影响。结果:紫外、红外光谱表明锌可与羧甲基壳聚糖发生络合反应;羧甲基壳聚糖—锌能显著提高饲高糖高脂大鼠SOD活性(P<0.05)。结论:羧甲基壳聚糖可与锌(Ⅱ)形成络合物,并能增强SOD活性。Objective： To prepare Zinc（Ⅱ）-carboxymethyl Chitosan complex and study its effect on serum SOD in high fat/high sucrose-fed Wistar rats..Methods： The coordination compounds of carboxymethyl Chitosan with Zinc（Ⅱ） were synthesized and studied by TJ-IR and UV-V.Its effects on serum SOD in the diabetic rats were investigated.Results ：TJ-IR and UV-V indicated Zinc element and carboxymethyl Chitosan could form a complex.The complex might improve SOD activity in high fat/high sucrose-fed Wistar rats（P0.05）.Conclusion： carboxymethyl Chitosan could form the cooperation thing with Zinc（II）.The complex might increase SOD activity.

关 键 词：羧甲基壳聚糖-锌(Ⅱ) 制备 SOD 

分 类 号：O623.67[理学—有机化学]