合成鱼腥草素对小鼠免疫功能的影响  

The Effects of Houttuyninum on Immunologic Function of Splenectomized Mice

作　　者：邵兰[1] 于庆海[1] 吴红艳 李霞[1] 

机构地区：[1]沈阳药科大学中药系

出　　处：《沈阳药科大学学报》1999年第3期209-211,共3页Journal of Shenyang Pharmaceutical University

摘　　要：对于脾切除致免疫功能低下小鼠，合成鱼腥草素（ＨＯＵ）６０ｍｇ／ｋｇ，１２０ｍｇ／ｋｇ灌胃给药均能增强其腹腔巨噬细胞的吞噬功能（Ｐ＜０００１）；迟发型超敏反应强度（Ｐ＜０００１）；明显提高血清溶血素水平（Ｐ＜００５；Ｐ＜０００１）；外周血淋巴细胞ＡＮＡＥ阳性百分率（Ｐ＜０００１）；ＨＯＵ６０ｍｇ／ｋｇ还能明显提高脾切小鼠腹股沟淋巴结中淋巴细胞个数（Ｐ＜００１），表明ＨＯＵ对脾切除致免疫功能低下小鼠的特异性、非特异性免疫功能均有明显增强作用．For the immunodeficiency mice following splenectomy,houttuyninum ig 60 mg/kg,120 mg/kg strikingly strengthened the phagocytosing function of the peritoneal macrophage system (P<0001),delayed the type hypersensitivity (DTH)reaction (P<0001);significantly enhanced the level of serumhemolysin(P<005;P<001),and ANAE(+) cell percentage of peripheral blood lymphocytes(P<0001)furthermore,60 mg/kg remarkably raised the amount of lymphocytes of groin lymph node(P<005).These experimental results of hottnyninum were suggested that houttuyninum could obviously strengthen the nonspecific and sepecific immune function in splenectomized mice.

关 键 词：合成鱼腥草素 脾切除 免疫增强 小鼠 HOU 

分 类 号：R979.5[医药卫生—药品]