溃疡性结肠炎患者血浆FPA、F1+2、AT-Ⅲ的变化及相关性研究  

The plasma levels of FPA、F1+2 and AT-Ⅲ in patients with ulcerative colitis and its correlation

作　　者：秦月花[1] 王兴木[1] 潘颖颖[1] 罗文文[1] 傅文安[1] 薛惠[1] 谢伟萍[1] 

机构地区：[1]绍兴市人民医院,浙江绍兴312000

出　　处：《中国卫生检验杂志》2011年第7期1666-1668,共3页Chinese Journal of Health Laboratory Technology

基　　金：绍兴市卫生局科研项目(2009A33008)

摘　　要：目的:探讨溃疡性结肠炎(UC)患者血浆FPA、F1+2、AT-Ⅲ的变化及相关性。方法:采用ELISA法检测30例活动期UC患者、20缓解期UC患者及20例对照者的血浆纤维蛋白肽A(FPA)、凝血酶原片段1+2(F1+2)、抗凝血酶-Ⅲ(AT-Ⅲ)水平。结果:血浆FPA、F1+2水平活动期UC高于缓解期UC及对照组、缓解期UC高于对照组;AT-Ⅲ水平活动期UC低于缓解期UC及对照组、缓解期UC低于对照组,各组比较差别有统计学意义(P<0.01);活动期UC患者随着疾病严重度加重及病变范围扩大,血浆FPA、F1+2水平升高(P<0.05)、血浆AT-Ⅲ水平下降,差别有统计学意义(P<0.01);FPA与AT-Ⅲ、F1+2与AT-Ⅲ的变化存在负相关(P<0.05)。结论:UC患者处于明显的血栓前状态,FPA、F1+2、AT-Ⅲ水平的变化与疾病活动性、疾病严重程度及病变累及范围有关。Objective：To study the levels of fibrinopeptide A（FPA）,prothrombin fragment1＋2（F1＋2） and antithrombin Ⅲ（AT-Ⅲ） in patients with ulcerative colitis（UC） and its correlation.Methods： The plasma levels of FPA,F1＋2 and AT-Ⅲ in 30 patients with active UC,20 patients with remissive UC and 20 controls were measured by enzyme linked immunosorbant assays（ELISA）.Results： The concertration of FPA,F1＋2 were significantly increased in patients with active UC compared with remissive UC and healthy contyols.The concertration of AT-Ⅲ were significantly decreased in patients with active UC compared with remissive UC and healthy contyols.（P〈0.01）.The concertration of FPA,F1＋2 in patients with active UC increased with increase of disease severity and the expansion of the lesion of UC（P〈0.05）,while the concertration of AT-Ⅲ decreased（P 0.01）.There were significantly negitive correlation between FPA and AT-Ⅲ,F1＋2 and AT-Ⅲ.Conclusion： There was an obvious prehtrombotic state in patients with UC.The levels of FPA,F1＋2,AT-Ⅲ were correlated with disease activity and severity and the range of the lesion of UC.

关 键 词：溃疡性结肠炎 纤维蛋白肽A 凝血酶原片段1+2 抗凝血酶-Ⅲ 

分 类 号：I574.62[文学—其他各国文学]