急性冠脉综合征血浆抗凝血酶与凝血指标的检测及其临床意义  

The detection and clinical significances of plasma antithrombin and coagulation indexes in acute coronary syndrome

作　　者：戴利亚[1] 李君[1] 张德亭[1] 

机构地区：[1]温州医学院温州市第三临床学院,浙江温州325000

出　　处：《中国卫生检验杂志》2011年第7期1753-1754,1756,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:检测急性冠脉综合征患者外周血抗凝血酶和凝血指标并评价临床意义。方法:急性冠脉综合征患者102例为ACS组,其中急性心肌梗死(AMI)49例,不稳定型心绞痛(UA)53例。测定凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、抗凝血酶活性(AT:A)、D-二聚体(D-D)。稳定型心绞痛组(SA)66例,正常人50例为对照组。结果:ACS组AT:A明显低于SA组及对照组,PT,APTT明显缩短、FIB及D-D明显升高(均P<0.01)。SA组与对照组各指标差别无统计学意义。AMI组与UA组比较:AT:A降低、PT和APTT缩短、FIB和D-D增高(P<0.01)。ACS组AT:A与FIB、D-D相关系数分别为r2=0.4751和r2=0.5612,P<0.05,有一定相关性。结论:抗凝血酶及凝血指标能及时反映ACS患者体内凝血和抗凝系统失衡情况,可作为有效预测急性心血管事件发生及危险分层的临床指标。Objective： To detect the PB antithrombin and coagulation indexes in patients with acute coronary syndrome and evaluate the clinical significances.Methods： 102 patients with acute coronary syndrome is the ACS Group（49 with acute myocardial infarction and 53 with unstable angina）,66 with stable angina is the SA group and 50 normal were studied as the control group.PT,APTT,FIB,AT：A and D-D were detected.Results： AT：A of acute coronary syndrome patients were much lower than those of the ones with stable angina and the normal,meanwhile PT and APTT showed shorter obviously,FIB and D-D much higher（P〈0.01）.There is no statistical significance in the index differences between the SA group and control group.AT：A lowered,PT and APTT shortened,FIB and D-D increased were the results when compared the AMI group with the UA group（P〈0.01）.Correlation coefficients were 0.4751 and 0.5612 respectively between AT：A and FIB,and between AT：A and D-D from patients with acute coronary syndrome which mean they have certain correlations（P〈0.05）.Conclusion： Antithrombin and levels of coagulation indexes can reflect the imbalance of coagulation and anticoagulatin system in patients with acute coronary syndrome,which can be taken as the clinical indicator to predict the occurrence of acute cardiovascular incident effectively and determine the risk stratification.

关 键 词：冠脉综合征 抗凝血酶 凝血指标 

分 类 号：R543.3[医药卫生—心血管疾病]