颐生母液对小鼠低氧游泳耐力和免疫形态学的观察  

Effect of Yi Sheng Mu Liquid on Swimming Endurance and Immune Function of Mice at High Altitude

作　　者：张梦岚[1] 齐文斌[1] 张淑坤[1] 周世英[1] 吴彩虹[1] 王建国[1] 贺菊香[2] 

机构地区：[1]青海省人民医院病理科,810007 [2]青海大学医学院病理教研室,810001

出　　处：《高原医学杂志》2011年第1期8-10,共3页Journal of High Altitude Medicine

摘　　要：目的:了解颐生母液对小鼠低氧游泳耐力和某些生理指标的影响。方法:在青海海晏县(海拔3 100m)进行小鼠低氧游泳耐力实验,将70只小鼠随机分为颐生母液高、中、低三种剂量组(分别灌服5g/kg、3.5g/kg和2.5g/kg)、阳性对照组(灌服红参水煎液)和空白对照组(灌服等体积蒸馏水),连续灌服10天。第11天进行游泳试验,观察记录游泳至死时间,并称小鼠体重和脾脏、胸腺重量,计算相关脏器指数。结果:颐生母液三种剂量组及红参组(阳性对照组)均能提高小鼠的低氧游泳耐力,游泳时间明显延长(P<0.05或P<0.01);而且胸腺指数、脾脏指数均高于对照组(P<0.05)。结论:颐生母液能明显减轻高原低氧环境对小鼠体能的影响,具有提高机体低氧耐力、免疫功能和抗疲劳的作用。Objective：To study the effects of Yi Sheng Mu liquid（a Tibetan medical preparation） on swimming endurance and immune function of mice under hypoxic condition.Methods：70 mice exposed to 3 100m altitudes（Haiyan county,Haibei state） from Xining city were randomly divided into 5 groups each 14 animals： the high-dosage（Yi Sheng Mu liquid 5g/kg,one daily）,middle-dosage（3.5g/kg）,low-dosage（2.5g/kg,one daily）,blank control（same volume of distilled water,one daily） and positive control group（red ginseng liquid,one daily）,and they were fed by gastric tube with above preparation for 10 days at Haiyan,respectively.On the day 11,exhaustive swimming test was carried out in a homemade tank.The exhaustive swimming time was recorded,while the weight of spleen and thymus were weighed to calculate the relative index of organs.Results：As compared with blank control group,the exhaustive swimming time in the four other medication groups significantly prolonged（P0.05 or P0.01）,and index of thymus and spleen increased too（P0.05）.Conclusions：Yi Sheng Mu liquid can enhance the swimming endurance and improve the immune function of mice at high altitude,and we characterized the mechanism on it.

关 键 词：颐生母液 低氧环境 小鼠 低氧耐力 免疫功能 

分 类 号：R285.5[医药卫生—中药学]