脐血促酰化蛋白水平测定与胎儿发育临床意义研究  

Plasma acylation-stimulating protein level of cord blood and its fetal growth significance

作　　者：郑俊虎 冯维良[1] 郑骆颖 杜文君[1] 林锋 王靖[1] 

机构地区：[1]瑞安市人民医院妇幼分院新生儿科,浙江瑞安325200

出　　处：《中国优生与遗传杂志》2011年第8期59-60,91,共3页Chinese Journal of Birth Health & Heredity

基　　金：温州市科技计划项目(Y20080048);瑞安市科技计划项目(20082087)

摘　　要：目的探讨脐血促酰化蛋白(ASP)水平与胎儿生长发育的关系。方法研究对象为大于胎龄儿(LGA)、适于胎龄儿(AGA)和小于胎龄儿(SGA)各30例。应用酶联免疫吸附法(ELISA)测定血浆促酰化蛋白和脂联素浓度,用免疫比浊法测定甘油三酯(TG)、总胆固醇(TCH)、低密度脂蛋白-胆固醇(LDL-c)、高密度脂蛋白-胆固醇(HDL-c)的水平;并分析脐血促酰化蛋白水平与脐血脂联素水平、母血促酰化蛋白水平、新生儿性别、出生体质量、体质量指数、胎盘重量和血脂水平的相关性。结果①LGA的脐血ASP水平高于AGA,AGA的脐血ASP水平高于SGA,差异有统计学意义(P<0.001),三组新生儿血脂水平差异无统计学意义(P>0.05)。②脐血ASP水平与新生儿出生体质量、BM、I脐血甘油三酯水平呈显著正相关(P<0.001),与血脂联素水平呈显著负相关(P<0.001),与母血ASP水平、胎盘重量无相关性(P>0.05)。③男、女婴脐血ASP、血脂各成分水平比较差异均无统计学意义(P>0.05)。结论促酰化蛋白参与胎儿生长发育调节,脐血ASP水平可反映胎儿的生长发育状况。Objective：To investigate the relationship between plasma acylation-stimulating protein（ASP） and growth and development among fetus.Methods：In the present study,30 LGA infants,30 AGA infants and 30 SGA infants were enrolled in.The concentration of ASP and serum adiponectin in plasma were measured by ELISA.Serum TG,TCH,LDL-c and-HDL-c were assayed with turbidimetry.the correlation between cord plasma ASP and adiponectin,matemal plasma ASP,newborn gender,birth weight,BMI,placental weight and blood lipids were analyzed.Results：①The levels of ASP in cord blood of LGA were significantly higher than that in AGA.The levels of ASP in cord blood of AGA were significantly higher than that in SGA,（P0.001）;The levels of blood fat had no statistically difference among three groups,（P0.05）.②The correlation analysis showed positive correlation between the levels of ASP in cord blood and body weight,BMI,TG in cord blood,（P0.001）.The correlation analysis showed negative correlation between the levels of ASP in cord blood and the levels of serum adiponectin,（P0.001）.There was no significant difference in levels of ASP between cord blood and maternal blood（P0.05）.There was no significant difference in levels of ASP between umbilical cord blood and placental weight（P0.05）.③There was no significant difference in levels of ASP or blood fat in cord blood between male infants and female infants（P0.05）.Conclucion：The ASP from umbilical cord blood is concerned with the adjustment of fetal growth.The levels of ASP can reflect the status of fetal growth.

关 键 词：促酰化蛋白 胎儿 血脂 体质指数 脐血 

分 类 号：R446.6[医药卫生—诊断学] R714.5[医药卫生—临床医学]