复方银杏叶对糖尿病大鼠附睾VEGF表达的影响  

Effectsof compound ginkgo leaf on VEGF of epididymis of diabetic rats

作　　者：徐秋玲[1] 郑学芝[1] 李丽[1] 

机构地区：[1]黑龙江省牡丹江医学院生理教研室黑龙江省高校肿瘤疾病防治重点实验室,157011

出　　处：《中国优生与遗传杂志》2011年第8期106-107,共2页Chinese Journal of Birth Health & Heredity

基　　金：黑龙江省卫生厅科研项目(2009-409)

摘　　要：目的探讨复方银杏叶(CGL)对糖尿病大鼠附睾VEGF的影响。方法 40只Wistar雄性大鼠随机抽取10只作为正常对照组(NC),其余大鼠用链脲佐菌素(Streptozotocin STZ)加高脂高糖饮食制备2型糖尿病模型,造模动物筛选后,随机分为糖尿病组(DM组)和CGL治疗组,每组10只。治疗组给予CGL 10周后,取双侧附睾组织,提取蛋白,检测组织中血管内皮生长因子(VEGF)含量。结果 2型糖尿病模型制备成功,糖尿病组与对照组比较,VEGF含量降低,差别有显著性意义(P<0.01),而治疗组与糖尿病组比较,VEGF升高,差别有显著性意义(P<0.01)。结论复方银杏叶能够提高糖尿病大鼠附睾VEGF的表达,对糖尿病伴随生殖功能障碍有一定的改善作用。Objective：To observe the effects of compound ginkgo leaf on VEGF of epididymis of diabetic rats.Methods：The normal control group was established with 10 randomly selected from forty male Wistar rats.The others were established type Ⅱ diabetes model with streptozotocin（STZ）and high lipid,high glucose diet,After filtrated,the type Ⅱ diabetes models were randomly divided into diabetic group and CGL-treated group,there were ten rats every group.CGL.treated group were given CGL.After ten weeks,the epididymis were taken out and extracted protein for vascular endothelial growth factor.Results：The type Ⅱdiabetes model was prepared successfully and compared with the normal control group,VEGF content of DM dropped sharply（P0.01）.VEGF content of CGL obviously increased（P0.01）,compared with the diabetic group.Conclusion：CGL can increase VEGF content of epididymis of diabetic rats and improve diabetes mellitus sexual disorder.

关 键 词：2型糖尿病大鼠 复方银杏叶 附睾 血管活性因子 

分 类 号：R285.5[医药卫生—中药学]