重组人表皮生长因子治疗儿童复发性口腔溃疡的疗效观察  

Observation on the clinical efficacy of recombinant human epidermal growth factor in treatment of recurrent oral ulcer in children

作　　者：胡哲勤[1] 杨湘晖[1] 龚博林[2] 

机构地区：[1]湖北省妇幼保健院口腔科,430070 [2]武汉大学口腔医学院东莞分院

出　　处：《中国妇幼保健》2011年第21期3255-3257,共3页Maternal and Child Health Care of China

摘　　要：目的:观察重组人表皮生长因子(金因肽,rhEGF)治疗儿童复发性口腔溃疡(RAU)的疗效。方法:109例复发性口腔溃疡患儿随机分为实验组57例,用金因肽喷于溃疡表面,3次/d;对照组52例用西瓜霜喷于溃疡表面,3次/d;比较两组溃疡愈合情况。结果:疼痛消失的时间实验组(3.92±1.53)天,对照组(5.09±2.07)天,两组比较差异有统计学意义(P<0.01);溃疡愈合时间实验组(4.97±2.21)天,对照组(6.22±2.90)天,两组比较差异有统计学意义(P<0.01)。结论:金因肽治疗儿童复发性口腔溃疡可缩短疼痛和治愈时间,值得临床推广。Objective：To observe the clinical efficacy of recombinant human epidermal growth factor（rhEGF） in treatment of recurrent oral ulcer（ROU） in children. Methods：109 children with ROU were divided into two groups randomly,57 children in experimental group were treated with rhEGF,three times a day;and 52 children in control group were treated with watermelon frost,three times a day,the healing situations of ulcer in the two groups were compared. Results：The disappearance times of pain in experimental group and control group were（3.92±1.53） days and（5.09±2.07） days,respectively,there was significant difference between the two groups（P0.01）.The healing times of ulcer in experimental group and control group were（4.97±2.21） days and（6.22±2.90） days,respectively,there was significant difference between the two groups（P0.01）. Conclusion：rhEGF can shorten the pain time and healing time in treatment of ROU,which is worthy to be popularized.

关 键 词：复发性口腔溃疡 重组人表皮生长因子 治疗 

分 类 号：R726[医药卫生—儿科]