低剂量率裂变中子长期照射对血清中超氧化物歧化酶和丙二醛的影响  

Effects of low dose rate neutron exposure on the serum superoxide dismutase and malondialdehyde

作　　者：马丽[1] 雷呈祥[1] 杨翊方[1] 

机构地区：[1]海军医学研究所,上海200433

出　　处：《中华航海医学与高气压医学杂志》2011年第3期133-135,共3页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：海军后勤部科研计划课题（02-3303）

摘　　要：目的 探讨低剂量率裂变中子长期照射对血清总超氧化物歧化酶（SOD）和丙二醛（MDA）的影响.方法 80只SD雄性大鼠按数字表法随机分成对照组和照射组,照射组每天用低剂量率（252Cf,吸收剂量率0.35 mGy/h）裂变中子照射20.5 h,在照射的第28、42、56、70天及停止照射后35 d各取8只大鼠,眼球取血分离血清,用化学比色法测定血清中总SOD活性和MDA含量.结果 与同一时间点对照组血清总SOD活性[（94.19±11.94）×103 U/L]比较,累积剂量为0.3 Gy的照射组血清总SOD活性[（68.75±8.07）×103 U/L]明显下降（P〈0.01）,其他剂量点与同一时间对照组比较差异无统计学意义（P〉0.05）.各个剂量点MDA与对照组相比较,差异均无统计学意义（P〉0.05）.结论 低剂量率（0.35 mGy/h）裂变中子长期照射对雄性大鼠SOD活性和MDA含量无明显影响.Objective To study the effects of low dose rate netron exposure on the serum superoxide dismutase （SOD） and malondialdehyde（MDA）.Methods Eighty male SD rats were randomly divided into the experimental and the control groups. Rats in the experimental group were exposed to 252Cf neutron at 0.35 mGy/h for 20.5 hours. On the 28th, 42nd, 56th, and 70th days during exposure and also 35 days after exposure, 8 rats were chosen from each group and the serum samples were collected to measure the activity of SOD and the content of MDA by colorimetric method.Results When compared with the control group[（94.19±11.94）×103 U/L]on the same day, the activity of serum superoxide dismutase （SOD） in the experimental group with an accumulated low dose rate of 0.3 Gy[（68.75±8.07）×103 U/L] decreased evidently （P〈0.01）. However, no statistical significance could be seen, when a comparison was made with that of the control group, at any check points （P〉0.05）. And there was also statistical difference in the contents of MDA at any check points, when a comparison was made between the two groups （P〉0.05）.Conclusions Our study indicated that prolonged exposure to low dose rate neutron （0.35 mGy/h） had no significant effects on the activity of serum SOD and the content of serum MDA in rats.

关 键 词：中子 低剂量率 大鼠 超氧化物歧化酶 丙二醛 

分 类 号：R285.5[医药卫生—中药学]