方格星虫多糖对小鼠抗辐射能力的影响  

Protective effect of polysaccharides from sipunculus nudus on radiation injury in mice

作　　者：李珂娴[1] 沈先荣[2] 蒋定文[2] 殷明[3] 

机构地区：[1]第二军医大学,上海200433 [2]海军医学研究所 [3]海后卫生部

出　　处：《中华航海医学与高气压医学杂志》2011年第3期139-141,共3页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的 探讨方格星虫（sipunculus nudus）多糖对辐射损伤小鼠的保护作用.方法 C57小鼠给予方格星虫多糖15 d后,用60Co γ射线进行8 Gy一次性全身照射,辐照后继续给药,观察照后30 d生存情况和照后3 d外周血细胞计数、血清超氧化物歧化酶（SOD）活性、丙二醛（MDA）含量.结果 方格星虫多糖能提高受照小鼠30 d存活率,延长其平均生存时间,提高机体的抗氧化能力.结论 方格星虫多糖对辐射损伤小鼠具有明显的保护作用,能提高小鼠的抗辐射能力.Objective To investigate the protective effect of polysaccharides from sipunculus nudus on radiation injury in mice. Methods C57 mice were lavaged with polysaccharides from sipunculus nudus for 15 days and then had whole-body radiation exposure to ^60Co γ （8 Gy）. After that, the mice continued to be lavaged with polysaccharides once a day. Observations were made to see the survival of the treated animals 30 days after exposure, and WBC, SOD and MDA levels in the serum were monitored 3 days after radiation. Results Polysaccharides from sipunculus nudus could increase the 30-day survival rate and prolong the average survival time of the radiated mice. Polysaccharides from sipunculus nudus could also improve anti-oxygenation of the radiated mice. Conclusions Polysaccharides from sipunculus nudus had obvious protective effect on radiated mice and improved the anti-radiation capacity of mice

关 键 词：方格星虫多糖 辐射损伤 抗氧化 

分 类 号：R28[医药卫生—中药学]