三仁汤对复合因素致脾胃湿热证大鼠行为学改变的干预作用研究  

Effect of Sanren decoction on the changes in the behavior of rats with spleen and stomach damp-heat syndrome induced by composite factors

作　　者：钟文[1] 李云鹏[2] 文小敏[3] 武凯歌[3] 洪冰[2] 

机构地区：[1]解放军第四二一医院,广州510318 [2]南方医科大学中西医结合医院 [3]南方医科大学中医药学院

出　　处：《中华航海医学与高气压医学杂志》2011年第3期146-149,共4页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：广东省中医药局科研基金（2008195）

摘　　要：目的 观察复合因素（外部湿热环境、高糖高脂饮食及病原微生物）致脾胃湿热证大鼠的行为学改变以及三仁汤对其干预作用.方法 50只雄性Wistar大鼠采用数字表法随机分为对照组、脾胃湿热证组、三仁汤高、中、低剂量组,通过旷场实验观察大鼠行为学改变,同时观察三仁汤对行为的改善情况.结果 脾胃湿热证大鼠行为发生改变,三仁汤对大鼠行为均有明显改善作用,三仁汤各剂量组与脾胃湿热证组比较差异有统计学意义（P〈0.05或P〈0.01）,但各剂量组间差异无统计学意义（P〉0.05）.结论 复合因素可以改变脾胃湿热证大鼠的行为学,三仁汤对其行为有干预作用.Objective To study the effect of composite factors （external damp and hot environment, high carbonhydrate and high fat diet and pathogenic microorganism） on the changes in the behavior of rats with spleen and stomach damp-heat syndrome and intervention effect of Sanren decoction.Methods Fifty male Wister rats were randomly divided into 5 groups： the normal control group, the model group （with spleen and stomach damp-heat syndrome） and the high, medium and low doses Sanren decoction groups. The behavior of the rats was monitored with open-field test and effect of Sanren decoction on behavior was also observed.Results Experiments showed that there were changes in the behavior of rats with spleen and stomach damp-heat syndrome. Sanren decoction with various doses had effect on the behavior of the rats（P〈0.05 or P〈0.01）, and significant statisfical differences could be seen, when they were compared with the rats with spleen and stomach dampheat syndrome. However, no statistical differences could be seen between groups treated with different doses（P〉0.05）.Conclusions Composite factors could change the behavior of the rats with spleen and stomach damp-heat syndrome, and Sanren decoction obviously had certain intervention effect on the behavior of rats.

关 键 词：三仁汤 脾胃湿热证 旷场实验 大鼠行为学 

分 类 号：R28[医药卫生—中药学]