高频超声评价川崎病不同病程中颈总动脉变化的初步研究  

Common Carotid Artery in Kawasaki Disease with High-Frequency Ultrasonography

作　　者：翟秀全[1] 计晓娟[1] 余更生[1] 白永虹[1] 郭军[1] 

机构地区：[1]重庆医科大学附属儿童医院,重庆市400014

出　　处：《中国超声医学杂志》2011年第7期639-642,共4页Chinese Journal of Ultrasound in Medicine

基　　金：重庆市自然科学基金(No.2009BB5267)

摘　　要：目的探讨应用高频超声评价急性期及远期川崎病患儿的颈总动脉内-中膜厚度及缓冲功能的价值。方法 50例受试者纳入试验。包括15例急性川崎病患者(急性期组),18例远期川崎病患儿(远期组),17例年龄匹配的健康儿童(对照组)。观察颈总动脉内-中膜厚度及颈动脉缓冲功能指标-横断面顺应性、容积扩张性及僵硬度指数。结果颈总动脉内-中膜厚度、僵硬度指数急性期组及远期组均高于对照组(P<0.05),容积扩张性急性期组与远期组均低于对照组,颈总动脉横断面顺应性远期组低于对照组(P<0.05),急性期组与对照组无明显差别(P>0.05)。颈总动脉内-中膜厚度与容积扩张性呈负相关(r=-0.301,P=0.034),与僵硬度指数呈正相关(r=0.289,P=0.042)。结论急性期及远期川崎病患儿均存在颈总动脉内-中膜增厚及缓冲功能的降低,高频超声可用于检测川崎病患儿颈动脉变化。Objective To study the value of detecting the carotid intima media thickness （C-IMT） and buffering function, including cross-sectional compliance （CSC）, volumic diatansibility （VD）, arterial stiffness index （ASI） in children with Kawasaki disease in acute stage and long-term stage with high-frequency ultrasonography. Methods 50 patients received ultrasonography, including 15 patients with Kawasaki disease in acute stage （acute stage group）, 18 patients with Kawasaki disease in long-term （long-term group） and 17 normal children （control group）. Results C-IMT and ASI of acute stage group and long-term group were significantly higher than that of control group （P〈 0.05）, VD of acute stage group and long-term group was significantly lower than that of control group （P〈0.05）, CSC of long-term group was lower than control group and acute stage, but there is no significant difference between acute stage group and control group. C-IMT negatively correlated with VD （r=0. 301, P= 0. 034）, and positively correlated with ASI （r=0. 289,P=0. 042）. Conclusions There were increased C-IMT and abnormal Buffering Function in the acute stage and long-term of Kawasaki disease. It is feasible to detect the change of common carotid artery with high-frequency ultrasonography.

关 键 词：颈动脉内-中膜厚度 缓冲功能川崎病 动脉粥样硬化 

分 类 号：R445.1[医药卫生—影像医学与核医学] R725.4[医药卫生—诊断学]