海藻酸多糖衍生物治疗大鼠骨质疏松(英文)  

Marine algae polysaccharide derivant in treatment of osteoporosis in rats

作　　者：司艳莉[1] 李冬霞[1] 刘友才[2] 千智斌[1] 

机构地区：[1]新乡医学院机能学实验室,河南省新乡市453003 [2]新乡医学院三全学院,河南省新乡市453003

出　　处：《中国组织工程研究与临床康复》2011年第24期4519-4521,共3页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:作者既往研究发现海藻酸多糖衍生物有促进骨细胞生长的作用。目的:探索海藻酸多糖衍生物治疗骨质疏松的效果。方法:60只Wistar雌性大鼠随机分成对照组,治疗组和模型组,每组20只。治疗组和模型组大鼠用维甲酸诱导产生骨质疏松模型。治疗组大鼠每只每公斤每天10mg多糖衍生物灌胃,模型组每只每公斤每天10mg葡萄糖灌胃,持续2周。观察大鼠股骨病理形态学和骨组织形态计量学变化。结果与结论:与对照组相比,模型组大鼠股骨骨小梁面积、平均骨小梁厚度、骨小梁密度显著降低,而髓腔质间隔宽度则明显增加;经过海藻多糖衍生物治疗后,治疗组大鼠股骨平均骨小梁密度,平均骨小梁厚度和骨小梁面积较模型组均显著上升,同时髓腔质间隔宽度明显下降;说明海藻酸性多糖能有效促进骨细胞生长,可治疗和预防骨质疏松。BACKGROUND：We have previously reported that marine algae polysaccharide derivant can significantly promote bone cell growth.OBJECTIVE：To observe the effect of marin algae polysaccharide derivant in treatment of osteoporosis.METHODS：Sixty female Wistar rats were randomly divided into control group,treatment group and model group.There were 20 rats in each group.The rats in treatment group and model group were respectively treated with retinoic acid to induce osteoporosis.The rats in treatment group were gavaged the marine algae polysaccharide derivant 10 mg/kg,and the rats in model group were gavaged the glucose 10 mg/kg orally for 14 days.Changes of rat femur bone histological examination and histomorphometry parameters were observed.RESULTS AND CONCLUSION：The mean Trabecular Number（Tb.N）,the mean Trabecular Thickness（Tb.Th） and the percent Trabecular Area（Tb.Ar%） were significantly decreased in the model group compared with control group.The mean trabecular separation（Tb.Sp） was greatly increased.After intake of marine algae polysaccharide derivant,Tb.N,Tb.Th and Tb.Ar% of the treatment group were significantly more than that of the model group.The Tb.Sp was obviously reduced.These indicate that marine algae polysaccharide derivant can increase bone mass and have a therapeutic and preventional effect on the osteoporosis.

关 键 词：海藻酸多糖衍生物 大鼠 骨质疏松 骨小梁 维甲酸 

分 类 号：R318[医药卫生—生物医学工程]