转化生长因子β1与骨生化指标和骨密度的关系(英文)  

Relationship of transforming growth factor beta 1 with bone turnover markers and bone mineral density

作　　者：皮银珍 廖二元[2] 

机构地区：[1]长沙市第一医院内分泌科,湖南省长沙市410006 [2]中南大学湘雅二医院代谢内分泌研究所,湖南省长沙市410011

出　　处：《中国组织工程研究与临床康复》2011年第24期4537-4540,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：the Key Clinical Project of Chinese Ministry of Health,No.2001035427~~

摘　　要：背景:转化生长因子β1是一种重要的调节骨构塑的细胞因子,其是否能作为反应骨转换的敏感因子尚不清楚。目的:探讨转化生长因子β1与骨形成、骨吸收指标,以及腰椎正位骨密度间的关系。方法:实验共纳入来自长沙的健康妇女663名,年龄20～80岁。采用ELISA法测定空腹血清转化生长因子β1、骨特异性碱性磷酸酶和Ⅰ型胶原羧基末端肽的水平,同时应用双能X射线骨密度仪测定腰椎正位的骨密度。并分析转化生长因子β1与其他各指标的相关性。结果与结论:检测结果显示30～39岁,40～49岁年龄段妇女的血清转化生长因子β1水平最高,转化生长因子β1水平与年龄呈负相关,与体质量指数无相关。校正体质量指数后发现,转化生长因子β1与骨特异性碱性磷酸酶和Ⅰ型胶原羧基末端肽负相关,校正体质量指数和年龄后血清转化生长因子β1水平与腰椎正位骨密度正相关。说明转化生长因子β1能动态地反映骨转换情况。BACKGROUND：Transforming growth factor-β1（TGF-β1） is an important cytokine in the regulation of bone remodeling.Whether it can be used as a sensitive marker to bone turnover is incompletely understood.OBJECTIVE：To investigate the relationship of TGF-β1 with bone formation and resorption markers,and bone mineral density（BMD） at the anteroposterior lumbar spine.METHODS：Totally 663 healthy women from Changsha were analyzed,aged 20-80 years.Levels of TGF-β1,serum bone alkaline phosphatase（sBAP） and serum C-terminal cross-linked telopeptides（sCTx） were measured by ELISA,at the same time,the BMD of anteroposterior lumbar spine was measured by dual-energy x-ray absorptiometry.The associations between TGF-β1 and other indexes were analyzed.RESULTS AND CONCLUSION：The TGF-β1 levels reached a peak in the 30-39 and 40-49 years groups,which had a negative correlation with age,but no correlation with body mass index（BMI）.After corrected for BMI,TGF-β1 was negatively correlated to sBAP and sCTx,but was positively correlated with BMD of spine after correction of BMI or age.TGF-β1 can act as a sensitive cytokine to reflect the changes of bone turnover.

关 键 词：血清转化生长因子Β1 双能X射线骨密度仪 骨生化指标 Ⅰ型胶原羧基末端肽 骨特异性碱性磷酸酶 体质量指数 ELISA法 健康妇女 

分 类 号：R318[医药卫生—生物医学工程]