多孔聚乙烯醇/明胶软骨组织工程支架复合材料的制备及其生物相容性  

Preparation and biocompatibility evaluation of composite scaffold material of polyvinyl alcohol/gelatin

作　　者：郭涛[1] 韩志[2] 杨天府[3] 李玉宝[4] 苑天红[5] 肖杰[1] 陈艺新[1] 

机构地区：[1]贵阳市第四人民医院骨科,贵州省贵阳市550002 [2]贵阳中医学院,贵州省贵阳市550002 [3]四川大学华西医院骨科,四川省成都市610041 [4]四川大学分析测试中心,四川省成都市610041 [5]贵阳医学院,贵州省贵阳市550004

出　　处：《中国组织工程研究与临床康复》2011年第25期4587-4590,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:以明胶为基体制备的组织工程支架材料具有良好的生物相容性和生物降解性能,但存在力学性能低,降解速率难以控制的缺陷。目的:制备一种软骨组织工程支架材料多孔聚乙烯醇/明胶复合物,并检测其理化性能和生物相容性。方法:采用乳化发泡法制备聚乙烯醇/明胶多孔支架,并通过电镜分析、力学测试、皮下植入实验,检测材料孔径和孔隙率、IR光谱、力学性能和生物相容性。结果与结论:多孔材料内部呈三维网状多孔结构,孔径均匀,有相似的孔隙率61.8%,含水率44.6%,抗拉强度为(5.01±0.03)MPa,抗压强度为(1.47±0.36)MPa,有较好的力学性能,IR光谱分析表明材料内部结构均匀。皮下植入后,炎症反应逐渐减轻,囊壁逐渐变薄,并趋于稳定,提示多孔聚乙烯醇/明胶支架材料具有较好的生物相容性和力学性能。BACKGROUND：The tissue engineered scaffolds prepared with gelatin as base have good biocompatibility and biodegradability,but low mechanical properties and difficulty to control degradation rate are their shortcomings.OBJECTIVE：To prepare a new type of composite scaffold material of polyvinyl alcohol/gelatin and to evaluate the biocompatibility of composite scaffold.METHODS：New type composite materials（polyvinyl alcohol/gelatin） were prepared by foaming method.The pore size and porosity,IR spectroscopy,mechanical performance and biocompatibility were detected by using scanning electron microscope,mechanical test and subcutaneous implantation test.RESULTS AND CONCLUSION：Composite materials（polyvinyl alcohol/gelatin） were three-dimensional porous structure.The pore size was even,and the porosity was 61.8%.The water content rate of the composite materials was 44.6%.The tensile strength was（5.01±0.03） MPa,and the compressive strength was（1.47±0.36） MPa.The new type composite materials have been proved to have good biocompatibility and biomechanical properties.

关 键 词：多孔聚乙烯醇 明胶 软骨组织工程 支架 复合材料 

分 类 号：R318[医药卫生—生物医学工程]