厄贝沙坦/氢氯噻嗪与硝苯地平控释片联合治疗高血压疗效评价  

Irbesartan/hydrochlorothiazide tablets and nifedipine controlled-release tablets in moderate to severe enssential hypertension

作　　者：王士强[1] 

机构地区：[1]安徽省淮北市人民医院心内科,235000

出　　处：《蚌埠医学院学报》2011年第7期733-735,共3页Journal of Bengbu Medical College

摘　　要：目的:观察厄贝沙坦/氢氯噻嗪片(含厄贝沙坦150 mg,氢氯噻嗪12.5 mg)与硝苯地平控释片(含硝苯地平30 mg)联合治疗高血压的临床疗效。方法:选择高血压患者78例,随机分为A组(口服厄贝沙坦/氢氯噻嗪片150 mg,每日1次)、B组(口服硝苯地平控释片30 mg,每日1次)、C组(晨服厄贝沙坦/氢氯噻嗪片150 mg,睡前服用硝苯地平控释片30 mg,每日1次),疗程均为12周。结果:3组患者血压均有下降(P<0.01),总有效率A组为61.9%,B组为64.0%,C组为93.8%,差异有统计学意义(P<0.05)。结论:厄贝沙坦/氢氯噻嗪联合硝苯地平控释片治疗高血压比单用厄贝沙坦/氢氯噻嗪片或硝苯地平控释片更有效、安全,值得推广。Objective：To observe the efficacy of irbesartan/hydrochlorothiazide tablets（IHT） and nifedipine controlled-release tablets（NCRT） in moderate to severe essential hypertension.Methods：Patients were randomly divided into A group（IHT 150 mg,per day,n=21）,B group（NCRT 30 mg per day,n=25）,C group（150 mg per morning,NCRT 30 mg per night,n=32）,three groups were all treated for 12 weeks.Results：Blood pressure of three groups all greatly decreased（P0.01）,the total effective rate in IHT groups was 61.9%;the total effective rate in NCRT groups was 64.0% the total effective rate in IHT ＋NCRT groups was 93.8%.Conclusions：IHT plus NCRT are more efficiency than IHT or NCRT group in the treatment of moderate to severe hypertension.So it deserve to popularize fore more efficiency and more security.

关 键 词：高血压 厄贝沙坦/氢氯噻嗪 硝苯地平 

分 类 号：R544.1[医药卫生—心血管疾病]