突发性取精困难时西地那非加舍曲林的应用  

Evaluation of Phosphodiesterase 5 inhibitors （PDE5-Is）, PDE5- Is＋Sertraline for treatment of unexpected ejaculation failure during an assisted reproductive technologies （ART）

作　　者：卢少明[1] 李晓[1] 张浩波[1] 颜军浩[1] 陈子江[1] 

机构地区：[1]山东大学附属省立医院生殖医学中心,济南250021

出　　处：《中国男科学杂志》2011年第4期36-38,共3页Chinese Journal of Andrology

摘　　要：目的探讨突发性取精困难的药物应急措施，为突发性取精困难寻求可行的有效治疗途径。方法回顾性分析药物治疗突发性取精困难患者60例，分成两组：A组为口服特异性磷酸二酯酶5（PDEs）抑制剂（西地那非）26例；B组为联合口服西地那非加抗抑郁药物（舍曲林）34例。两组患者均辅以心理治疗。比较两组取出精液的成功率。结果A组成功取出精液17例，占65．1％，B组成功取出精液31例，占91．2％，差异有统计学意义。结论心理紧张、焦虑是引起突发性取精困难重要原因，联合使用西地那非＋舍曲林能有效缓解患者精神压力，唤起性欲，达到性高潮，完成取精过程，是治疗突发性取精困难有效途径。Objective To evaluate the two emergency drugs for treatment of unexpected ejaculation failure Methods Total of 60 patients with unexpected temporary ejaculation failure during treatments with assisted reproductive technologies were retrospectively analyzed. All patients were divided into Group 1（26 patients with Phos- phodiesterase 5 inhibitors,PDE5-Is）; and Group 2（34 patients with PDE5-Is＋Sertraline）. Results Of 26 patients in group 1, 17 （65.1%） produced sperm samples sucessfully, and 31 patients （91.2%） in group 2 produced sperm samples There was a significantly difference in treatment between these two groups. Conclusion The combined use of PDE5- Is＋Sertraline might attenuate the stress of patients, and correct unpredictable ejaculation failure successfully on the day of ART, compared with Vardenafil alone

关 键 词：取精术 环核苷酸磷酸二酯酶类 5型/拮抗剂和抑制剂 舍曲林 

分 类 号：R698.1[医药卫生—泌尿科学]