CRP等指标与成人重症肺炎预后关系的探讨  

C-reactive protein,clinical indicators and prognosis of severe pneumonia in adults

作　　者：何安南[1] 陈兴无[2] 

机构地区：[1]皖南医学院附属芜湖市第二人民医院呼吸内科,安徽芜湖241000 [2]皖南医学院附属弋矶山医院呼吸内科,安徽芜湖241001

出　　处：《皖南医学院学报》2011年第4期282-284,共3页Journal of Wannan Medical College

摘　　要：目的:观察重症社区获得性肺炎(SCAP)治疗期间C反应蛋白(CRP)、体温(T)、白细胞总数(WBC)、动脉血气(PaO2)、继发器官功能衰竭评分(SOFA)的变化,研究CRP与临床指标对于重症肺炎预后评估的价值。方法:回顾性分析重症监护室的SCAP患者从住院第1天至第7天CRP水平、T、WBC、PaO2及总SOFA变化,按照存活组及死亡组进行比较。结果:两组患者CRP、T、WBC、PaO2及总SOFA评分阳性率无显著差异,住院期间存活组CRP水平、WBC及SOFA评分从第3天开始明显下降、入院3 d CRP降低>50%,T及PaO2趋于正常;而死亡组CRP水平及SOFA评分下降缓慢,且T、WBC及PaO2改善不明显。两组每日CRP水平及SOFA评分差异显著。结论:连续进行CRP、SOFA监测对判断重症肺炎预后有价值。Objective：To estimate the role of C-reactive protein（CRP） and clinical indicators,including temperature（T）,white blood cell（WBC） count,arterial blood gas（PaO2）and secondary organ failure assessment（SOFA） in prognosis for patients with severe community-acquired pneumonia（SCAP）.Methods：SCAP patients were divided into groups of survival and death and retrospectively analyzed regarding the changes of CRP levels,T,WBC,PaO2 and SOFA from the 1st to 7th day of ICU stay.Results：The two groups had no significant difference in positive rates of CRP,T,WBC,PaO2 and total SOFA scores,yet,CRP levels,WBC and SOFA scores were decreased significantly from the 3rd day 3 for the survivals,particularly,CRP was reduced by 50%,and T and PaO2 tended to be normal by the 3rd day after admission.Delayed decrease of CRP levels and SOFA scores were found in the deaths,and T,WBC and PaO2 had no evident changes.The daily CRP levels were significantly different between the two groups.Conclusion：CRP measurement and SOFA monitoring by around-the-clock may be important to estimate the prognosis for patients with SCAP.

关 键 词：重症社区获得性肺炎 C-反应蛋白 预后 

分 类 号：R563.1[医药卫生—呼吸系统]