大黄对有机磷中毒患者多器官功能障碍综合征的防治研究  

Therapeutic and preventive effects of rhubarb on multiple organ dysfunction syndrome in patients with acute organophosphorus pesticide poisoning

作　　者：薛成[1] 王伟华[1] 

机构地区：[1]皖南医学院附属弋矶山医院急诊内科,安徽芜湖241001

出　　处：《皖南医学院学报》2011年第4期308-310,共3页Journal of Wannan Medical College

摘　　要：目的:研究大黄对急性有机磷农药中毒(AOPP)患者胃肠道功能的保护作用及防治多器官功能障碍综合征(MODS)的机制。方法:89例重度AOPP患者随机分为大黄治疗组和对照组,观察两组患者胃肠道功能障碍及MODS的发生率,并测定血浆内皮素-1(EF1)和肿瘤坏死因子(TNF)水平。结果:大黄治疗组患者胃肠道功能障碍及MODS的发病率均明显低于对照组(P<0.01)。结论:大黄可以通过拮抗重度AOPP患者炎症介质和血管活性物质的过度释放,保护胃肠功能,对MODS具有显著的防治作用。Objective：To investigate the therapeutic and preventive effects of rhubarb on gastrointestinal tract and multiple organ dysfunction syndrome（MODS） in patients with acute organophosphorus pesticide poisoning（AOPP）.Methods： Eighty-nine patients with serious AOPP were randomized into rhubarb treatment group（n=45） and controls（n=44）,in which the incidence of gastrointestinal dysfunction and MODS were observed,with determination of the levels of plasma endothelin（ET-1） and tumor necrosis factor（TNF）.Results： The incidence of gastrointestinal dysfunction and MODS was found lower in rhubarb treatment group as compared with the controls（P0.01）,and the levels of ET-1 and TNF were significant decreased after treatment（P0.01）.Conclusion： Rhubarb may improve the gastrointestinal function and produce preventive effects on MODS in AOPP through inhibiting plasma ET-1 and TNF.

关 键 词：大黄 有机磷中毒 多器官功能障碍综合征 

分 类 号：R595.4[医药卫生—内科学]