能量分辨质谱鉴别卤代4(3H)-喹唑啉酮异构体  

Identification of Isomers of Halogen-Substituted 4(3H)-Quinazolinone by Energy Resolution-Mass Spectrometry

作　　者：刘伟[1] 叶学敏[2] 崔晓楠[1] 马永萍[2] 莫卫民[2] 

机构地区：[1]浙江工业大学化学工程与材料学院 [2]浙江工业大学分析测试中心,杭州310014

出　　处：《理化检验（化学分册）》2011年第7期757-760,770,共5页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

摘　　要：应用能量分辨质谱分别研究了氯代4(3H)-喹唑啉酮异构体和氟代4(3H)-喹唑啉酮异构体的单体及异构体单体的混合物的能量质谱裂分曲线。结果表明,在碰撞能量0.8～1.5V的变化范围内,氯代4(3H)-喹唑啉酮异构体单体及混合物的碎片离子m/z 145与m/z 125的离子强度比值相对于碰撞能量的变化曲线,即裂分曲线与氯官能团的取代位置密切相关,而氟代4(3H)-喹唑啉酮异构体单体及混合物的碎片离子m/z 136与m/z 108的离子强度比值的裂分曲线则与氟官能团的取代位置密切相关,差异显著;据此可以成功鉴别卤代4(3H)-喹唑啉酮异构体的单体及混合物的构成。Energy resolution-mass spectrometry was applied to the study of fragmentation curves of the individual monomer and mixtures of monomers of isomers of chloro-substituted and fluoro-substituted 4（3H）- quinazolinones.It was shown that the fragmentation curves showing changes of ionic intensity ratios of fragment ions of m/z 145 to m/z 125 of monomers or monomer mixtures of the chloro-substituted isomers,and of ionic intensity ratios of fragment ions of m/z 136 to m/z 108 of monomers or monomer mixtures of the fluoro-substituted isomers as plotting against the values of different collision energy in the range of 0.8-1.5 V were found to be closely related with the positions substituted by halogens in molecules of the isomers.Based on the obvious differences among the fragmentation curves,isomers of the halogen substituted 4（3H）-quinazolinones could be identified successfully.

关 键 词：能量分辨质谱 鉴别 卤代4(3H)-喹唑啉酮 异构体 裂分曲线 

分 类 号：O657.63[理学—分析化学]