Silica-bonded S-sulfonic Acid as a Recyclable Catalyst for Synthesis of 2,3-Dihydroquinazolin-4（1H）-ones  

作　　者：Niknam, Khodabakhsh Mohammadizadeh, Mohammad Reza Mirzaee, Salimeh 

机构地区：[1]Chemistry Department, Faculty of Sciences, Persian Gulf University, Bushehr, 75169, Iran

出　　处：《Chinese Journal of Chemistry》2011年第7期1417-1422,共6页中国化学（英文版）

摘　　要：2,3-Dihydroquinazolin-4（1H）-one derivatives were synthesized via a one-pot, three component reaction of isatoic anhydride and an aromatic aldehyde with ammonium acetate or primary amine catalyzed by silica-bonded S-sulfonic acid in ethanol at 80 ℃. The reaction work-up is simple and the catalyst is easily separated from the products by filtration. The heterogeneous catalyst was recycled for ten runs upon the condensation reaction of isa- toic anhydride and 4-chlorobenzaldehyde with ammonium acetate without losing its catalytic activity.2,3-Dihydroquinazolin-4（1H）-one derivatives were synthesized via a one-pot, three component reaction of isatoic anhydride and an aromatic aldehyde with ammonium acetate or primary amine catalyzed by silica-bonded S-sulfonic acid in ethanol at 80 ℃. The reaction work-up is simple and the catalyst is easily separated from the products by filtration. The heterogeneous catalyst was recycled for ten runs upon the condensation reaction of isa- toic anhydride and 4-chlorobenzaldehyde with ammonium acetate without losing its catalytic activity.

关 键 词：silica-bonded S-sulfonic acid aldehydes 2 3-dihydroquinazolin-4（1H）-one isatoic anhydride amines 

分 类 号：TQ426.8[化学工程] TQ455.47