Isosteviol-amino Acid Conjugates as Highly Efficient Organocatalysts for the Asymmetric One-pot Three-component Mannich Reactions  

作　　者：安雅洁 秦倩 王川川 陶京朝 

机构地区：[1]Department of Chemistry, New Drug Research and Development Center, Zhengzhou University, Zhengzhou, Henan 450052, China

出　　处：《Chinese Journal of Chemistry》2011年第7期1511-1517,共7页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation Of China （No. 20772113）.

摘　　要：Isosteviol-amino acid conjugates were synthesized and used as chiral catalysts for the asymmetric three-component Mannich reaction with hydroxyacetone as donor molecule. Good yields （up to 98%） and excellent stereoselectivities （up to 97 ： 3 dr and 99% ee） were achieved in a short reaction time. In addition, syn- or anti-configurations of a-hydroxy-β-amino carbonyl compounds were obtained as main products with different chiral catalysts.Isosteviol-amino acid conjugates were synthesized and used as chiral catalysts for the asymmetric three-component Mannich reaction with hydroxyacetone as donor molecule. Good yields （up to 98%） and excellent stereoselectivities （up to 97 ： 3 dr and 99% ee） were achieved in a short reaction time. In addition, syn- or anti-configurations of a-hydroxy-β-amino carbonyl compounds were obtained as main products with different chiral catalysts.

关 键 词：isosteviol-amino acid conjugates asymmetric catalysis mannich reaction HYDROXYACETONE enantiose- lectivity 

分 类 号：TQ94[化学工程] Q517[生物学—生物化学]