Advances of multiplex and high throughput biomolecular detection technologies based on encoding microparticles  

作　　者：ZHAO XiangWei, ZHAO YuanJin & GU ZhongZe State Key Laboratory of Bioelectronics Southeast University, Nanjing 210096, China 

出　　处：《Science China Chemistry》2011年第8期1185-1201,共17页中国科学（化学英文版）

基　　金：support of Grant for Teaching and Research of Excellent Young Teachers in Southeast University;333 Talent Project Foundation and the Qing Lan Project of Jiangsu Province;Jiangsu Science and Technology Department (BE2009148 & Bk2008318);the National Natural Science Foundation of China (50925309, 20703010 & 21073033);the Scientific Research Foundation of the Graduate School of Southeast University

摘　　要：The rapid developments of genomics and proteomics have driven the demand for multiplex and high throughput analysis of large numbers of biomolecules in the fields of medical diagnostics, drug discovery, and environmental monitoring. Encoding the biomolecular binding events is the key technique to fulfill this demand, in which microparticles play the most important roles. This review outlines the development of multiplex and high throughput biodetections, and highlights the most recent advances in the field of encoding microparticles, together with problems that need to be resolved.The rapid developments of genomics and proteomics have driven the demand for multiplex and high throughput analysis of large numbers of biomolecules in the fields of medical diagnostics, drug discovery, and environmental monitoring. Encoding the biomolecular binding events is the key technique to fulfill this demand, in which microparticles play the most important roles. This review outlines the development of multiplex and high throughput biodetections, and highlights the most recent advances in the field of encoding microparticles, together with problems that need to be resolved.

关 键 词：multiplex bioassays multiplex labels encoded microcarrier binding assays high throughput screening 

分 类 号：Q503[生物学—生物化学] X703[环境科学与工程—环境工程]