Methylprednisolone intrathecal injections suppress neuronal apoptosis following acute spinal cord injury  

作　　者：Xinghua Song Jianjun Zhang Liwen Ding Li Cao Xiaoxiong Xu Hao Wen 

机构地区：[1]Department of Orthopedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China [2]Teaching Department, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China [3]General Department, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China

出　　处：《Neural Regeneration Research》2011年第17期1306-1312,共7页中国神经再生研究（英文版）

基　　金：the Research Fund of First Affiliated Hospital,Xinjiang Medical University,China,No.2008-YFY-05;the Postgraduate Fund of the First Affiliated Hospital,Xinjiang Medical University,No.2010PGF01

摘　　要：High dose methylprednisolone intravenous injections are effective in treating acute spinal cord injury but can have severe side effects. In this study, we investigated intrathecal delivery of methylprednisolone for the treatment of spinal cord injury. In particular, we examined the effects of varying doses of methylprednisolone intrathecal injections on neuronal apoptosis induced by secondary damage. The results demonstrate that intrathecal injections inhibit the expression of interleukin-lβ, significantly lower expression of caspase-3, and reduce the number of apoptotic neurons, High dose methylprednisolone （0.75 mg/μL） was much more effective at reducing neuronal apoptosis than low dose methvlprednisolone （0.01 ma/μL.High dose methylprednisolone intravenous injections are effective in treating acute spinal cord injury but can have severe side effects. In this study, we investigated intrathecal delivery of methylprednisolone for the treatment of spinal cord injury. In particular, we examined the effects of varying doses of methylprednisolone intrathecal injections on neuronal apoptosis induced by secondary damage. The results demonstrate that intrathecal injections inhibit the expression of interleukin-lβ, significantly lower expression of caspase-3, and reduce the number of apoptotic neurons, High dose methylprednisolone （0.75 mg/μL） was much more effective at reducing neuronal apoptosis than low dose methvlprednisolone （0.01 ma/μL.

关 键 词：spinal cord injury APOPTOSIS interleukin-1 receptor antagonist CASPASE-3 METHYLPREDNISOLONE neural regeneration 

分 类 号：S857.18[农业科学—临床兽医学] Q421[农业科学—兽医学]