Antidepressant mechanism of Jieyu No.1 decoction in a rat model of depression  

作　　者：Liping Zhang Li Wu Meng Xia Xueli Shi Man Zhang Chi Tan Rui Yang 

机构地区：[1]Department of Basic Theory of Traditional Chinese Medicine, School of Basic Medicine, Guangxi Traditional Chinese Medical University,Nanning 300073, Guangxi Zhuang Autonomous Region, China

出　　处：《Neural Regeneration Research》2011年第18期1386-1390,共5页中国神经再生研究（英文版）

基　　金：the National Natural Science Foundation of China, No. 30660231

摘　　要：Rats were subjected to unpredictable chronic stress and isolation-induced depression, and were then intragastrically perfused with Jieyu No.1 decoction or amitriptyline water solution for 21 consecutive days. Open-field test showed that Jieyu No.1 decoction and amitriptyline water solution significantly improved the abnormal behaviors of the depressed rats; it reduced plasma surfactant protein, corticosterone, and corticotropin releasing hormone levels, increased neuropeptide Y and somatostatin levels, and upregulated interleukin-ll3, -2, -6 protein expression in the hippocampal CA3 region. Somatostatin and interleukin-l[3 protein expression were negatively correlated with corticosterone level, and interleukin-113 protein expression was negatively correlated with corticotropin releasing hormone level. Results demonstrated that Jieyu No.1 decoction improved abnormal behaviors of depressed animals by regulating the function of the neuroimmunoendocrine system.Rats were subjected to unpredictable chronic stress and isolation-induced depression, and were then intragastrically perfused with Jieyu No.1 decoction or amitriptyline water solution for 21 consecutive days. Open-field test showed that Jieyu No.1 decoction and amitriptyline water solution significantly improved the abnormal behaviors of the depressed rats; it reduced plasma surfactant protein, corticosterone, and corticotropin releasing hormone levels, increased neuropeptide Y and somatostatin levels, and upregulated interleukin-ll3, -2, -6 protein expression in the hippocampal CA3 region. Somatostatin and interleukin-l[3 protein expression were negatively correlated with corticosterone level, and interleukin-113 protein expression was negatively correlated with corticotropin releasing hormone level. Results demonstrated that Jieyu No.1 decoction improved abnormal behaviors of depressed animals by regulating the function of the neuroimmunoendocrine system.

关 键 词：modified Wendan decoction DEPRESSION model ANIMAL neuroimmunoendocrine neural regeneration 

分 类 号：S858.966[农业科学—临床兽医学] R749.4[农业科学—兽医学]