新辅助化疗对局部晚期宫颈癌低氧诱导因子-1αmRNA表达的影响  

Influence of Neoadjuvant Chemotherapy on Expression of HIF-1αmRNA in Locally Advanced Cervical Cancer

作　　者：梁桂玲[1] 梁宁安[1] 杨钦灵[1] 张桂萍[1] 洪红[1] 

机构地区：[1]钦州市第二人民医院妇产科,广西钦州535000

出　　处：《现代生物医学进展》2011年第15期2945-2947,3000,共4页Progress in Modern Biomedicine

基　　金：广西卫生厅自筹经费科研课题基金资助项目(Z2010099)

摘　　要：目的:探讨新辅助化疗PF方案的两种给药途径(子宫动脉置管与静脉全身化疗)对宫颈癌低氧诱导因子-1α(HIF-1α)表达的影响及其临床意义。方法:应用RT-PCR方法测定43例局部晚期宫颈癌病人子宫动脉置管与静脉全身化疗后癌组织的研究缺氧诱导因子(HIF-1α)mRNA表达的影响,评价化疗近期效果。结果:局部晚期宫颈癌患者经子宫动脉置管与静脉全身化疗比较,临床缓解率相似,但是前者能显著减少化疗引起的骨髓抑制和肝功能损害作用,子宫动脉置管组HIF-1αmRNA表达较静脉全身化疗组明显降低(P<0.05)。结论:术前子宫动脉置管PF方案化疗,能降低宫颈癌组织的HIF-1αmRNA表达,能减小肿瘤体积,减少化疗的不良反应,改善患者的预后,是一种可行、有效的辅助治疗手段。Objective： To study difference expression of HIF-1α mRNA in the locally advanced cervical cancer tissues（LACC） and clinical significance through different neoadjuvant chemotherapy approaches （uterine artery intervention and peripheral intravenous） with PF regimens. Methods： Detect the mRNA expression of HIF-1α in LACC tissues by quantitative real-time polymerase chain reaction （qRT-PCR）. The effectiveness of chemotherapy was assessed. Results. Compared with peripheral intravenous chemotherapy, the rate of clinical remission were similar in LACC patients with uterine artery intervention, but the latter can significantly reduce the chemotherapy-induced bone marrow suppression and liver damage effects. The former levels of HIF-1α mRNA expression in LACC tissues significantly lower （P〈0.05）. Conclusion： Interventional chemotherapy can effectively reduce the expressions of HIF-1α , reduce the tumor volume ,reduce side effects of chemotherapy and improve prognosis of cervical cancer,Which is a feasible and effective treatment for locally advanced cervical cancer.

关 键 词：局部晚期宫颈癌 新辅助化疗 缺氧诱导因子-1Α 

分 类 号：R711.76[医药卫生—妇产科学]