2004～2005年广西HIV-1耐药横断面调查  

Investigation of HIV-1 drug resistance prevalence in Guangxi from 2004 to 2005

作　　者：梁淑家[1] 刘伟[1] 李敬云[2] 陈杰[1] 李韩平[2] 梁富雄[1] 韦凯[1] 罗觅[1] 李国装[1] 

机构地区：[1]广西壮族自治区疾病预防控制中心,南宁530028 [2]中国军事医学科学院微生物流行病研究所全军艾滋病检测中心,北京100071

出　　处：《应用预防医学》2011年第3期129-131,共3页Applied Preventive Medicine

基　　金：广西壮族自治区卫生厅重点科研课题(重200415)

摘　　要：目的了解广西壮族自治区未接受抗病毒治疗的HIV感染者和已经接受抗病毒治疗一段时间的AIDS病人中的耐药情况。方法收集我区2004～2005年部分HIV感染者的全血标本201份,其中未接受抗病毒治疗的56人(27.86%),已接受抗病毒治疗的145人(72.14%),分别对他们进行问卷调查,并采集10毫升的抗凝血,分别进行CD4检测、病毒载量测定和基因型耐药检测。结果在未接受抗病毒治疗的HIV感染者中有耐药性的有9例,占17.65%,在已经接受抗病毒治疗并达半年以上的AIDS病人中耐药的有7例,占12.5%。结论我区不管在艾滋病感染者中还是在已经接受抗病毒治疗的艾滋病病人中都有一定的HIV-1耐药株流行。我们应该积极做好预防措施,及时干预,防止耐药株的大量流行。Objective To understand HIV-1 drug resistance prevalence from non-antiretroviral therapy HIV-1 infected persons and the patients with AIDS accepting antiretroviral therapy（ART） for a period of time in Guangxi.Methods 210 whole blood samples from the non-ART HIV-1 infected persons and the patients with AIDS accepting ART for a period of time were collected in 2004 and 2005.The questionnaire survey and CD4 lymphocyte count were conducted and the HIV-1 RNA viral load was also determined.When HIV-1 RNA viral load was more than 1 000 copies/mL,HIV-1 genotype drug resistance test was done.Results In the non ART HIV-1 positive persons,CD4 lymphocyte counts of 20 persons and 36 persons were below 200cells/μL,and more than 200cells/μL,respectively.The HIV-1 RNA viral loads of 15 persons and 41 perons were below 1 000copies/mL,and more than 1 000copies/mL,respectively.In non-ART HIV-1 infected persons,9 persons occurred the drug resistance.In accepting ART group CD4 lymphocyte counts of 84 persons and 61 persons were bellow 200 cells/μL,and more than 200cells/μL,respectively.The HIV-1 RNA viral loads of 122 persons and 23 persons were below 1000copies/mL and more than 1 000copies/mL.respectively.And there were 7 cases in resisting to some antiviral drugs.Conclusion According to above-mentioned results we consider that the HIV-1 drug resistance prevalence has occurred in the non ART HIV-1 positive persons and the patients with AIDS accepting ART for a period of time in Guangxi.So,we should take effective measures to prevent HIV-1 drug resistance prevalence in Guangxi.

关 键 词：HIV-1 横断面调查 抗病毒治疗 耐药 

分 类 号：R512.915[医药卫生—内科学]