糖脂清对高脂血症家兔糖脂代谢及肝组织的影响  

Effect of Tangzhiqing on Glycolipin Metabolism and Hepatic Histopathology in Rabbits with Hyperlipoidemia

作　　者：柳占彪[1] 李玉红[1] 张少卓[1] 师咏梅[1] 张德芹[1] 

机构地区：[1]天津中医药大学中医药研究院天津市中药药理学重点实验室,天津300193

出　　处：《中国实验方剂学杂志》2011年第15期135-138,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技重大专项课题重大新药创制项目(2009ZX09102-128)

摘　　要：目的:观察糖脂清(TZQ)对高脂血症家兔糖脂代谢及肝组织的影响。方法:采用高脂饲料喂养建立高脂血症家兔模型,用TZQ以生药3.2,1.6,0.8 g.kg-1剂量,ig连续治疗30 d,测定血清总胆固醇(TC)、游离脂肪酸(FFA)、葡萄糖(Glu)及肝组织甘油三酯(TG)、糖原含量,观察肝脏组织病理形态变化。结果:糖脂清可降低高脂血症模型兔血清TC,FFA,Glu的含量(P<0.01,P<0.05);减少肝组织TG和糖原的蓄积(P<0.01,P<0.05);减轻肝组织的脂肪变性(P<0.01)。结论:糖脂清具有调节机体TC,FFA,Glu的代谢,减少肝组织TG和糖原的蓄积以及保护肝损伤的作用。Objective：To observe the effect of Tangzhiqing（TZQ） on glycolipin metabolism and hepatic histopathology in rabbits with hyperlipoidemia.Method：Rabbit model of hyperlipoidemia was established by feeding high lipid diet.The treatment of TZQ was applied by intragastric administration at dosage of 3.2,1.6,0.8 g·kg-1 respectively for 30 days.The serum content of total cholesterol（TC）,free fatty acid（FFA）,glucose（Glu） and the accumulation of liver triglyeride（TG） and glucogen were determined and the histopathological changes in liver were observed.Result：The serumal content of TC,FFA.Glu and the accumulation of liver TG and glucogen were reduced（P〈0.01,P〈0.05）,fatty degeneration of the liver were lightened（by rank sum test,P〈0.01）in treated group of TZQ.Conclusion：TZQ can regulate the metabolic process of TC,FFA,Glu and decrease the accumulation of liver TG and glucogen,meanwhile has protective effect on hepatic injury in rabbits with hyperlipoidemia.

关 键 词：高脂血症 糖脂清 糖脂代谢 病理形态 

分 类 号：R285.5[医药卫生—中药学]